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Table 2 Common applications of aerosol therapy in intensive carea

From: Fundamentals of aerosol therapy in critical care

  Drug class
Feature Bronchodilators Anti-inflammatory Antimicrobial agents Vasoactive agents Heliox
Indications Bronchospasm (e.g. acute asthma, COPD exacerbation) Airway inflammation (e.g. acute asthma or COPD exacerbation, acute interstitial lung disease) MDR tracheobronchitis MDR pneumonia Right ventricular failure Asthma
Aspergillus prevention (lung transplant) Pulmonary hypertension
Site of action Airways Airways or alveoli Airways or alveoli Alveoli Airways
Preferred device pMDI with spacer pMDI with spacer VMN VMN  
Drugs Beta-agonists (e.g. salbutamol, salmeterol) Budesonide Antibiotics (e.g. tobramycin, colistin, amikacin, ceftazidime, amphotericin B) Epoprostenol Helium
Anticholinergics (e.g. ipratropium, tiotropium) Fluticasone Iloprost
Formulations available Yes Yes Some Yes  
  1. Table derived from references [19, 24, 37, 87, 132151]
  2. aAnaesthetic gases were not in the objectives of this analysis
  3. Heliox helium and oxygen, COPD chronic obstructive pulmonary disease, MDR multidrug resistant, pMDI pressurized metered dose inhaler, VMN vibrating mesh nebulizer