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Table 3 Respiratory mechanics, gas exchange and outcome of the patients divided according to lower or higher airway driving pressure at PEEP 15 cmH2O

From: Airway driving pressure and lung stress in ARDS patients

Variable Overall population (N = 150) Lower airway driving pressure (<15 cmH2O) (N = 97) Higher airway driving pressure (≥15 cmH2O) (N = 53) p value
Airway driving pressure (cmH2O) 13.2 [11.2–16.9] 11.9 [10.2–13.0] 18.0 [16.6–19.9] <0.001
Transpulmonary driving pressure (cmH2O) 9.5 [7.8–12.2] 8.4 [6.6–9.7] 13.1 [10.4–15.5] <0.001
End-inspiratory airway plateau pressure (cmH2O) 28.4 [25.8–31.3] 26.7 [24.8–28.2] 32.9 [30.8–35.1] <0.001
Lung stress (cmH2O) 20.7 [17.9–23.1] 19.3 [16.8–21.7] 23.9 [20.8–26.2] <0.001
Respiratory system elastance (cmH2O/L) 26.3 [21.2–32.2] 22.8 [19.5–26.6] 34.2 [29.6–41.9] <0.001
Lung elastance (cmH2O/L) 18.7 [14.5–24.2] 16.7 [13.1–19.7] 24.6 [19.5–31.3] <0.001
Chest wall elastance (cmH2O/L) 7.0 [4.8–10.3] 6.2 [4.6–8.2] 10.2 [5.9–12.3] <0.001
PaCO2 (mmHg)a 45 [40.2–50.4] 43.8 [39.0–49] 46.8 [41.9–53.2] 0.039
PaO2/FiO2 ratioa 178 [137–237] 175 [136–230] 187 [146–257] 0.314
ICU mortality N (%) 48 (32.0) 28 (28.9) 20 (37.7) 0.352
  1. Lung mechanics and gas exchange variables were determined at PEEP 15 cmH2O. Statistical analysis: Mann-Whitney rank sum test, chi-square, as appropriate
  2. Abbreviations: PEEP positive end-expiratory pressure, PaCO 2 arterial partial pressure of carbon dioxide, PaO 2 arterial partial pressure of oxygen, FiO 2 inspired fraction of oxygen, ICU intensive care unit
  3. aData available in 91 patients (64 in the “lower airway driving pressure” group and 27 in the “higher airway driving pressure” group)