Skip to main content

Advertisement

Table 2 INTERACT 2 [71] vs ATACH 2 [77] studies

From: The critical care management of spontaneous intracranial hemorrhage: a contemporary review

  INTERACT 2 (n = 2794) ATACH 2 (n = 1000)
  Control Intervention Control Intervention
Number of enrolled patients 1430 1399 500 500
Treatment target (SBP in mmHg) <180 <140 140–179 110–139
Inclusion criteria GCS > 5 ICH (volume < 60 cm3), GCS score ≥ 5
Primary outcome Death or major disability (mRS = 3–6) at 3 months Death or disability (mRS = 4–6) at 3 months
Recruitment window 6 hours 4.5 hours
Medications used to lower blood pressure Urapidil: 32.5 % Nicardipine ± labetalol
Nicardipine or nimodipine: 16.2 % Intravenous diltiazem or urapidil could be used
Labetalol: 14.4 %
Nitroglycerin: 14.9 %
Furosemide: 12.4 %
Nitroprusside: 12.1 %
Hydralazine: 5.9 %
Period of blood pressure intervention 7 days 24 hours
Time goal of blood pressure lowering 1 hour 2 hours
Mean interval between symptom onset and randomization 3.7 hours 3.7 hours 3.0 hours 3.0 hours
Systolic blood pressure at presentation (mmHg) 179 ± 17 179 ± 17 201.1 ± 26.9 200 ± 27.1
Mean systolic blood pressure achieved (mmHg) 164 within 1 hour 150 within 1 hour 141.1 ± 14.8 (2 hours) 128.9 ± 16 (2 hours)
153 within 6 hours 139 within 6 hours
Primary treatment failurea (%) 66 12.2
Baseline hematoma volume (ml) 11 11 10.2 10.3
Asian (%) 68.0 67.7 57.0 55.4
Death or disability (%)—mRS = 3–6 55.6 52.0 56.1 56.2
Modified Rankin Scale (%)     
 0 7.6 8.1 7.1 5.0
 1 18.0 21.1 19.6 19.8
 2 18.8 18.7 17.3 19.1
 3 16.6 15.9 18.3 17.5
 4 19.0 18.1 26.5 26.0
 5 8.0 6.0 4.2 5.8
 6 12.0 12.0 7.1 6.9
  1. aPrimary treatment failure was defined as target SBP < 140 mmHg not achieved within 1 hour of randomization in the intensive-treatment group in the INTERACT 2 trial or within 2 hours in the ATACH 2 trial
  2. GCS Glasgow Coma Scale, ICH intracerebral hemorrhage, mRS modified Rankin Scale, SBP systolic blood pressure