Table 2 INTERACT 2 [71] vs ATACH 2 [77] studies
From: The critical care management of spontaneous intracranial hemorrhage: a contemporary review
|  | INTERACT 2 (n = 2794) | ATACH 2 (n = 1000) | ||
|---|---|---|---|---|
| Â | Control | Intervention | Control | Intervention |
Number of enrolled patients | 1430 | 1399 | 500 | 500 |
Treatment target (SBP in mmHg) | <180 | <140 | 140–179 | 110–139 |
Inclusion criteria | GCS > 5 | ICH (volume < 60 cm3), GCS score ≥ 5 | ||
Primary outcome | Death or major disability (mRS = 3–6) at 3 months | Death or disability (mRS = 4–6) at 3 months | ||
Recruitment window | 6Â hours | 4.5Â hours | ||
Medications used to lower blood pressure | Urapidil: 32.5 % | Nicardipine ± labetalol | ||
Nicardipine or nimodipine: 16.2Â % | Intravenous diltiazem or urapidil could be used | |||
Labetalol: 14.4Â % | ||||
Nitroglycerin: 14.9Â % | ||||
Furosemide: 12.4Â % | ||||
Nitroprusside: 12.1Â % | ||||
Hydralazine: 5.9Â % | ||||
Period of blood pressure intervention | 7Â days | 24Â hours | ||
Time goal of blood pressure lowering | 1Â hour | 2Â hours | ||
Mean interval between symptom onset and randomization | 3.7Â hours | 3.7Â hours | 3.0Â hours | 3.0Â hours |
Systolic blood pressure at presentation (mmHg) | 179 ± 17 | 179 ± 17 | 201.1 ± 26.9 | 200 ± 27.1 |
Mean systolic blood pressure achieved (mmHg) | 164 within 1 hour | 150 within 1 hour | 141.1 ± 14.8 (2 hours) | 128.9 ± 16 (2 hours) |
153 within 6Â hours | 139 within 6Â hours | |||
Primary treatment failurea (%) | 66 | 12.2 | ||
Baseline hematoma volume (ml) | 11 | 11 | 10.2 | 10.3 |
Asian (%) | 68.0 | 67.7 | 57.0 | 55.4 |
Death or disability (%)—mRS = 3–6 | 55.6 | 52.0 | 56.1 | 56.2 |
Modified Rankin Scale (%) | Â | Â | Â | Â |
 0 | 7.6 | 8.1 | 7.1 | 5.0 |
 1 | 18.0 | 21.1 | 19.6 | 19.8 |
 2 | 18.8 | 18.7 | 17.3 | 19.1 |
 3 | 16.6 | 15.9 | 18.3 | 17.5 |
 4 | 19.0 | 18.1 | 26.5 | 26.0 |
 5 | 8.0 | 6.0 | 4.2 | 5.8 |
 6 | 12.0 | 12.0 | 7.1 | 6.9 |