TY - JOUR AU - van Vught, Lonneke A. AU - Scicluna, Brendon P. AU - Hoogendijk, Arie J. AU - Wiewel, Maryse A. AU - Klein Klouwenberg, Peter M. C. AU - Cremer, Olaf L. AU - Horn, Janneke AU - Nürnberg, Peter AU - Bonten, Marc M. J. AU - Schultz, Marcus J. AU - van der Poll, Tom PY - 2016 DA - 2016/08/06 TI - Association of diabetes and diabetes treatment with the host response in critically ill sepsis patients JO - Critical Care SP - 252 VL - 20 IS - 1 AB - Diabetes is associated with chronic inflammation and activation of the vascular endothelium and the coagulation system, which in a more acute manner are also observed in sepsis. Insulin and metformin exert immune modulatory effects. In this study, we aimed to determine the association of diabetes and preadmission insulin and metformin use with sepsis outcome and host response. SN - 1364-8535 UR - https://doi.org/10.1186/s13054-016-1429-8 DO - 10.1186/s13054-016-1429-8 ID - van Vught2016 ER -