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Table 4 Acetaminophen absorption: post-dose vs. baseline comparison (excluding the n = 2 without adequate camicinal exposures)

From: The effect of camicinal (GSK962040), a motilin agonist, on gastric emptying and glucose absorption in feed-intolerant critically ill patients: a randomized, blinded, placebo-controlled, clinical trial

Plasma acetaminophen Comparison Baseline Post study drug Point estimate 95 % CI
(mean) (mean)
C60 (ug/mL)* 50 mg (n = 15) 4.308 6.741 1.565 (0.962, 2.545)
50 mg (n = 13)# 4.708 7.043 1.496 (0.874, 2.560)
75 mg (n = 6) 5.398 6.315 1.170 (0.568, 2.409)
Placebo (n = 12) 6.291 6.609 1.051 (0.630, 1.751)
AUC(0–60) (ug.min/mL)* 50 mg (n = 15) 159.31 256.93 1.61 (0.97, 2.67)
50 mg (n = 13)# 169.80 293.52 1.73 (0.99, 3.03)
75 mg (n = 6) 210.81 239.86 1.14 (0.54, 2.41)
Placebo (n = 12) 224.21 230.08 1.03 (0.60, 1.74)
  1. CI confidence interval, AUC area under the curve
  2. *Log-transformed
  3. #Two subjects administered 50 mg camicinal had low drug exposure. Analyses were performed with and without these subjects