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Table 4 Acetaminophen absorption: post-dose vs. baseline comparison (excluding the n = 2 without adequate camicinal exposures)

From: The effect of camicinal (GSK962040), a motilin agonist, on gastric emptying and glucose absorption in feed-intolerant critically ill patients: a randomized, blinded, placebo-controlled, clinical trial

Plasma acetaminophen

Comparison

Baseline

Post study drug

Point estimate

95 % CI

(mean)

(mean)

C60 (ug/mL)*

50 mg (n = 15)

4.308

6.741

1.565

(0.962, 2.545)

50 mg (n = 13)#

4.708

7.043

1.496

(0.874, 2.560)

75 mg (n = 6)

5.398

6.315

1.170

(0.568, 2.409)

Placebo (n = 12)

6.291

6.609

1.051

(0.630, 1.751)

AUC(0–60) (ug.min/mL)*

50 mg (n = 15)

159.31

256.93

1.61

(0.97, 2.67)

50 mg (n = 13)#

169.80

293.52

1.73

(0.99, 3.03)

75 mg (n = 6)

210.81

239.86

1.14

(0.54, 2.41)

Placebo (n = 12)

224.21

230.08

1.03

(0.60, 1.74)

  1. CI confidence interval, AUC area under the curve
  2. *Log-transformed
  3. #Two subjects administered 50 mg camicinal had low drug exposure. Analyses were performed with and without these subjects
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Critical Care

ISSN: 1364-8535