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Table 2 Gastric emptying measured by 13C-octanoic acid breath test: baseline vs. post study drug comparison

From: The effect of camicinal (GSK962040), a motilin agonist, on gastric emptying and glucose absorption in feed-intolerant critically ill patients: a randomized, blinded, placebo-controlled, clinical trial

13C-octanoic acid breath test parameters Comparison Baseline (mean) Post study drug (mean) Point estimate 95 % CI
BTt½ (min)* 50 mg (n = 15) 117 76 0.65 (0.39, 1.08)
50 mg (n = 13)# 121 65 0.54 (0.32, 0.91)
75 mg (n = 6) 46 85 1.85 (0.82, 4.15)
Placebo (n = 12) 57 69 1.21 (0.68, 2.15)
GEC 50 mg (n = 15) 2.51 2.82 0.31 (−0.16, 0.77)
50 mg (n = 13)# 2.51 3.05 0.55 (0.09, 1.00)
75 mg (n = 6) 3.09 2.60 −0.49 (−1.23, 0.25)
Placebo (n = 12) 2.90 2.83 −0.06 (−0.58, 0.46)
  1. Least squares means and point estimates are geometric least squares means and ratios for log-transformed parameters. #Two subjects administered 50 mg camicinal had low drug exposure. Analyses were performed with and without these subjects
  2. BTt½ breath test gastric time to half emptying, GEC gastric emptying coefficient
  3. *Log-transformed