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Table 2 Gastric emptying measured by 13C-octanoic acid breath test: baseline vs. post study drug comparison

From: The effect of camicinal (GSK962040), a motilin agonist, on gastric emptying and glucose absorption in feed-intolerant critically ill patients: a randomized, blinded, placebo-controlled, clinical trial

13C-octanoic acid breath test parameters

Comparison

Baseline (mean)

Post study drug (mean)

Point estimate

95 % CI

BTt½ (min)*

50 mg (n = 15)

117

76

0.65

(0.39, 1.08)

50 mg (n = 13)#

121

65

0.54

(0.32, 0.91)

75 mg (n = 6)

46

85

1.85

(0.82, 4.15)

Placebo (n = 12)

57

69

1.21

(0.68, 2.15)

GEC

50 mg (n = 15)

2.51

2.82

0.31

(−0.16, 0.77)

50 mg (n = 13)#

2.51

3.05

0.55

(0.09, 1.00)

75 mg (n = 6)

3.09

2.60

−0.49

(−1.23, 0.25)

Placebo (n = 12)

2.90

2.83

−0.06

(−0.58, 0.46)

  1. Least squares means and point estimates are geometric least squares means and ratios for log-transformed parameters. #Two subjects administered 50 mg camicinal had low drug exposure. Analyses were performed with and without these subjects
  2. BTt½ breath test gastric time to half emptying, GEC gastric emptying coefficient
  3. *Log-transformed
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Critical Care

ISSN: 1364-8535