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Table 4 Evolution of total hepatic blood flow and perfusion parameters at different time points

From: Effects of dexmedetomidine and esmolol on systemic hemodynamics and exogenous lactate clearance in early experimental septic shock

Control-DEX

      

Variable

Group

A

B

C

D

p a

SpO2 (%)

Control

81 ± 11

82 ± 7.1

78 ± 7.8

68 ± 11

a

DEX

87 ± 6.0

85 ± 7.0

82 ± 8.3

78 ± 16

 

ShO2 (%)

Control

75 ± 7.5

79 ± 5.2

72 ± 4.6

69 ± 14

 

DEX

76 ± 5.9

76 ± 6.1

74 ± 8.1

68 ± 17

a

Portal vein lactate (mmol/L)

Control

2.0 ± 0.5

4.2 ± 1.4

6.4 ± 1.0

8.1 ± 1.1

a

DEX

1.7 ± 0.5

2.9 ± 1.5

3.7 ± 1.8*

6.2 ± 0.9*

a

Hepatic vein lactate (mmol/L)

Control

1.7 ± 0.5

4.4 ± 1.7

6.0 ± 1.1

7.3 ± 1.2

a

DEX

1.4 ± 0.6

2.8 ± 1.6

3.4 ± 0.4*

5.8 ± 0.8*

a

Total hepatic blood flow (ml/kg/min)

Control

30 ± 8.8

36 ± 5.4

28 ± 7.7

25 ± 7.9

a

DEX

27 ± 8.1

34 ± 5.6

23 ± 3.9

21 ± 4.9

 

Control-ESM

      

Variable

Group

A

B

C

D

p a

SpO2 (%)

Control

81 ± 11

82 ± 7.1

78 ± 7.8

68 ± 11

a

ESM

80 ± 6.1

79 ± 8.1

69 ± 12

75 ± 12

 

ShO2 (%)

Control

75 ± 7.5

79 ± 5.2

72 ± 4.6

69 ± 14

 

ESM

70 ± 11

70 ± 16

68 ± 12

62 ± 23

 

Portal vein lactate (mmol/L)

Control

2.0 ± 0.5

4.2 ± 1.4

6.4 ± 1.0

8.1 ± 1.1

a

ESM

1.1 ± 0.4*

2.4 ± 0.7*

2.9 ± 0.9*

4.0 ± 1.1*

a

Hepatic vein lactate (mmol/L)

Control

1.7 ± 0.5

4.4 ± 1.7

6.0 ± 1.1

7.3 ± 1.2

a

ESM

1.2 ± 0.4*

2.2 ± 0.6*

2.8 ± 1.0*

3.6 ± 1.4*

a

Total hepatic blood flow (ml/kg/min)

Control

30 ± 8.8

36 ± 5.4

28 ± 7.7

25 ± 7.9

a

ESM

39 ± 8.0

37 ± 14

32 ± 13

28 ± 11

 
  1. Values are presented as mean ± standard deviation (SD)
  2. DEX dexmedetomidine, SpO 2 portal vein oxygen saturation, ShO 2 hepatic vein oxygen saturation, ESM esmolol
  3. p < 0.05 considered as significant
  4. aSignificant changes over time within groups (comparison made with Friedman test and post hoc Bonferroni correction)
  5. *Significant difference between control group and DEX or ESM groups, respectively at the same time point (comparison made with Mann-Whitney U test)