Skip to main content

Table 3 Evolution of serum lactate, muscle lactate, epinephrine levels, and exogenous lactate clearance at different time points

From: Effects of dexmedetomidine and esmolol on systemic hemodynamics and exogenous lactate clearance in early experimental septic shock

Control-DEX

      

Variable

Group

A

B

C

D

p a

Arterial lactate (mmol/L)

Control

2.0 ± 0.5

5.1 ± 1.8

8.1 ± 1.7

9.2 ± 1.8

a

DEX

1.7 ± 0.5

3.4 ± 1.9

4.1 ± 1.9*

6.4 ± 3.1

a

Muscle lactate (mmol/L)

Control

3.8 ± 2.0

4.6 ± 1.3

5.1 ± 1.3

6.9 ± 3.5

a

DEX

5.2 ± 4.4

4.9 ± 2.1

6.7 ± 3.6

6.7 ± 2.4

 

Epinephrine levels (ng/ml)

Control

5.8 ± 4.3

5.6 ± 4.3

6.9 ± 4.2

7.3 ± 1.4

 

DEX

4.1 ± 1.8

3.2 ± 1.5

3.9 ± 3.6

4.6 ± 1.3*

 

Lactate clearance (ml/kg/min)

Control

   

2.43 ± 1.14

 

DEX

   

6.97 ± 1.60*

 

Control-ESM

      

Variable

Group

A

B

C

D

p a

Arterial lactate (mmol/L)

Control

2.0 ± 0.5

5.1 ± 1.8

8.1 ± 1.7

9.2 ± 1.8

a

 

ESM

1.6 ± 0.4

3.7 ± 0.9

3.6 ± 1.0*

4.5 ± 1.1*

a

Muscle lactate (mmol/L)

Control

3.8 ± 2.0

4.6 ± 1.3

5.1 ± 1.3

6.9 ± 3.5

a

ESM

3.3 ± 1.7

3.6 ± 3.2

5.0 ± 3.8

5.4 ± 2.6

 

Epinephrine levels (ng/ml)

Control

5.8 ± 4.3

5.6 ± 4.3

6.9 ± 4.2

7.3 ± 1.4

 

ESM

4.8 ± 3.6

5.8 ± 7.1

9.0 ± 3.2

7.1 ± 2.4

 

Lactate clearance (ml/kg/min)

Control

   

2.43 ± 1.14

 

ESM

   

7.32 ± 2.20*

 
  1. Values are presented as mean ± standard deviation (SD)
  2. DEX dexmedetomidine, ESM esmolol
  3. p < 0.05 considered as significant
  4. aSignificant changes over time within groups (comparison made with Friedman test and post hoc Bonferroni correction)
  5. *Significant difference between control group and DEX or ESM groups, respectively at the same time point (comparison made with Mann-Whitney U test)