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Table 1 Comparison of hemodynamic variables between LPS-control and LPS-DEX group along the study period

From: Effects of dexmedetomidine and esmolol on systemic hemodynamics and exogenous lactate clearance in early experimental septic shock

Variable

Group

A

B

C

D

p a

HR (bpm)

Control

127 ± 25

143 ± 16

137 ± 15

125 ± 20

 

DEX

139 ± 14

146 ± 27

128 ± 32

129 ± 30

 

MAP (mmHg)

Control

88 ± 14

67 ± 14

59 ± 5

61 ± 7

a

DEX

99 ± 20

63 ± 6

62 ± 12

58 ± 13

a

CO (ml/kg/min)

Control

78.3 ± 12.7

90.6 ± 26.4

80.0 ± 29.5

75.1 ± 23.1

 

DEX

89.0 ± 27.2

109 ± 21.2

92.1 ± 28.2

72.0 ± 25.9

 

MPAP (mmHg)

Control

14 ± 2

20 ± 4

23 ± 9

23 ± 10

a

DEX

13 ± 3

19 ± 7

21 ± 6

28 ± 5

a

PAOP (mmHg)

Control

8 ± 1

8 ± 1

7 ± 1

7 ± 1

 

DEX

9 ± 3

6 ± 2

7 ± 2

7 ± 3

 

SvO2 (%)

Control

74 ± 4.5

78 ± 7.0

74 ± 10

69 ± 9.3

 

DEX

75 ± 5.5

77 ± 5.9

72 ± 5.9

68 ± 12

 

P(v-a)CO2 (mmHg)

Control

4.7 ± 2.9

4.4 ± 3.6

6.9 ± 4.6

5.8 ± 4.0

 

DEX

4.1 ± 3.7

4.2 ± 1.8

3.5 ± 2.0

7.1 ± 1.1

 

NE (μg/kg/min)

Control

 

0.77 ± 0.52

1.34 ± 0.6

1.88 ± 1.31

a

DEX

 

1.08 ± 0.36

1.46 ± 0.38

1.62 ± 0.45

a

  1. Values are presented as mean ± standard deviation (SD)
  2. LPS lipopolysaccharide, DEX dexmedetomidine, HR heart rate, MAP mean arterial pressure, CO cardiac output, MPAP mean pulmonary arterial pressure, PAOP pulmonary artery occlusion pressure, SvO 2 mixed venous oxygen saturation, p(v-a)CO 2 mixed venous to arterial carbon dioxide partial pressure gradient, NE norepinephrine
  3. p < 0.05 considered as significant
  4. aSignificant changes over time within groups (comparison made with Friedman test and post hoc Bonferroni correction)