The predictive value of early acute kidney injury for long-term survival and quality of life of critically ill patients

Table 2 Crude outcomes

	Total population	RIFLE class				P value
		No eAKI	Risk	Injury	Failure
Number at study inclusion	2420	1588	456	253	123
Composite outcome
Poor outcome	1157/2420 (47.8 %)	694/1588 (43.7 %)	224/456 (49.1 %)	151/253 (59.7 %)	89/123 (72.4 %)	<0.001
Mortality^a
ICU mortality	411 (17 %)	215 (13.5 %)	90 (19.7 %)	65 (25.7 %)	41 (33.3 %)	<0.001
Hospital mortality	592 (24.5 %)	334 (21 %)	117 (25.7 %)	86 (34 %)	55 (44.7 %)	<0.001
One-year mortality	871 (36 %)	503 (31.7 %)	172 (37.7 %)	122 (48.2 %)	74 (60.2 %)	<0.001
Health-related quality of life in one-year survivors
EQ-5D response	1020/1549 (65.8 %)	735/1085 (67.7 %)	181/284 (63.7 %)	76/131 (58 %)	28/49 (57.1 %)	0.057
EQ-5D index score	0.806 (0.59-0.94)	0.81 (0.64-1.00)	0.778 (0.57-0.89)	0.772 (0.47-0.87)	0.666 (0.37-0.85)	0.076
Low HRQoL^b	286/1549 (18.5 %)	191/1085 (17.6 %)	52/284 (18.3 %)	29/131 (22.1 %)	15/49 (30.6 %)	0.927

Values are expressed as number (percentage) for categorical variables and as median (interquartile range) for continuous variables. Results were pooled from 35 imputation datasets, using Rubin’s rule to pool statistical test results. ^aNumbers for ICU, hospital and one-year mortality are cumulative; ^bLow health related quality of life (HRQoL) was defined as a EuroQoL 5D-3L™ questionnaire (EQ-5D) index below 0.4. RIFLE risk, injury, failure, loss, end-stage renal failure, eAKI early acute kidney injury, ICU intensive care unit

ISSN: 1364-8535