Long-term outcome in ICU patients with acute kidney injury treated with renal replacement therapy: a prospective cohort study

Table 3 Renal recovery and development of end-stage renal disease in patients with acute-on-chronic kidney disease versus patients without preexisting chronic kidney disease (subgroup analysis in patients with known reference baseline serum creatinine concentration)

Kidney outcome	Total	Preexisting CKD KDIGO stage <3	Preexisting CKD KDIGO stage ≥3	P value
Hospital discharge
Complete renal recovery, %	47.8	47.2	51.3	0.055
Incomplete renal recovery, %	38.4	45.7	32.3
Dialysis dependence, %	13.8	7.1	14.6
90 days
Complete renal recovery, %	56.7	55.8	65.2	*0.010*
Incomplete renal recovery, %	28.1	34.6	15.2
Dialysis dependence, %	15.2	9.6	19.7
1 year
Complete renal recovery, %	48.4	47.4	57.1	*0.001*
Incomplete renal recovery, %	32.6	45.3	22.1
Dialysis dependence, %	19.0	7.4	20.8
2 years
Complete renal recovery, %	41.5	34.7	57.1	*<0.001*
Incomplete renal recovery, %	39.5	61.1	22.2
Dialysis dependence, %	19.0	4.2	20.6
3 years
Complete renal recovery, %	39.8	39.1	51.0	*<0.001*
Incomplete renal recovery, %	32.0	51.6	15.7
Dialysis dependence, %	28.1	9.4	33.3
MAKE
Hospital discharge, %	83.1	87.3	51.0	*<0.001*
90 days, %	86.0	81.9	78.2	0.280
1 year, %	87.5	87.4	79.4	*0.010*
2 years, %	92.4	92.4	84.2	*0.002*
3 years, %	93.7	92.4	88.5	0.124

Abbreviations: CKD chronic kidney disease, KDIGO Kidney Disease: Improving Global Outcomes, MAKE major adverse kidney events
Renal recovery was defined as complete when estimated glomerular filtration rate (eGFR) was within 25 % of baseline eGFR. Incomplete kidney recovery was defined as patients with an eGFR decrease of 25 % or more from baseline eGFR without need for dialysis. Dialysis dependence was defined as end-stage kidney disease and permanent need for renal replacement therapy for >3 months
Statistically significant data (P<0.05) are presented in bolditalic

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