Variation in diurnal sedation in mechanically ventilated patients who are managed with a sedation protocol alone or a sedation protocol and daily interruption

Table 6 Variables associated with the patient not being liberated from mechanical ventilation despite passing the spontaneous breathing trial, multivariable analysis

	Odds ratio	95 % CI		P value
	Odds ratio	lower	upper	P value
Sedation protocol and daily interruption vs. sedation protocol alone	0.957	0.644	1.421	0.83
Age (10-year increase)	1.124	0.987	1.280	0.08
Gender (male vs female)	1.420	0.967	2.086	0.07
Surgical/trauma vs medical	1.066	0.630	1.804	0.81
Daytime midazolam dose (1 mg increase)	1.008	0.999	1.017	0.07
Midazolam: nighttime-daytime dose (1 mg increase)	1.014	1.004	1.025	0.007
Daytime fentanyl dose (100 mcg increase)	1.012	0.961	1.067	0.64
Fentanyl: nighttime-daytime dose (100 mcg increase)	0.974	0.906	1.047	0.48

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