Variation in diurnal sedation in mechanically ventilated patients who are managed with a sedation protocol alone or a sedation protocol and daily interruption

Table 1 Baseline characteristics of patients

Characteristic	Protocolized sedation and daily interruption	Protocolized sedation
Characteristic	n = 214	n = 209
Age, years, median (IQR)	57 (46–70)	60 (49–70)
Female sex, n (%)	93 (44)	92 (44)
Type of admission, n (%)
Medical	175 (82)	179 (86)
Surgical	30 (14)	22 (11)
Trauma	8 (4)	6 (3)
Body mass index, median (IQR)	28.2 (23.8–34.2)	28.6 (25.0–33.2)
APACHE II, median (IQR)	24 (18–28)	23 (19–29)
Mechanical ventilation days, median (IQR)	2 (1–4)	2 (1–4)
Pre ICU conditions, n (%)
Alcohol use	49 (23.0)	44 (21.2)
Tobacco use	48 (22.5)	40 (19.3)
Any psychiatric condition	42 (19.6)	29 (14.4)
Any neurologic condition	33 (15.4)	36 (17.2)
Respiratory disease	17 (8.0)	26 (12.4)
Renal dysfunction	20 (9.4)	16 (7.7)
Habitual drug use	14 (6.6)	10 (4.8)
Liver disease	12 (5.6)	11 (5.3)

Baseline demographic data for patients randomized to each arm of the SLEAP study. There were no significant differences between the two groups. Pre ICU conditions: neurological condition defined as stroke, seizure disorder, dementia, neuromuscular disease, Parkinson’s disease, or other neurological condition; psychiatric condition includes depression, bipolar disorder, schizophrenia, anxiety disorder, or other psychiatric condition; respiratory disease defined as home oxygen, CO₂ retention at baseline, or home ventilation; renal dysfunction defined as chronic renal failure with creatinine >180 umol/L, or chronic dialysis; habitual drug use other than tobacco or alcohol; liver disease defined as Child Pugh grade C or known esophageal varices. IQR interquartile range, APACHE II Acute Physiology and Chronic Health Evaluation II.

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