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Table 3 Plasma protein concentrations by neutropenia statusa

From: Neutropenic sepsis is associated with distinct clinical and biological characteristics: a cohort study of severe sepsis

 

Total population

No exogenous G-CSFb

Plasma protein

Non-neutropenic

(n = 216)

Neutropenic (n = 29)

p c

Non-neutropenic

(n = 212)

Neutropenic

(n = 13)

p c

ANG2 (pg/ml)

8242 (4039, 16694)

9165 (2708, 17244)

0.65

8252 (3918, 16694)

9475 (3168, 18936

0.68

IL1RA (pg/ml)

1269 (243, 5202)

1049 (103, 5329)

0.77

1346 (249, 3205)

534 (198, 3717)

0.52

IL-6 (pg/ml)

249 (76, 752)

457 (181, 1117)

0.03

249 (75, 773)

457 (281, 1117)

0.11

IL-8 (pg/ml)

94 (27, 600)

581 (358, 1576)

<0.01

93 (27, 600)

478 (361, 1681)

<0.01

G-CSF (pg/ml)

99 (29, 474)

3624 (919, 10099)

<0.01

90 (33, 331)

6660 (3411, 9045)

<0.01

  1. G-CSF granulocyte colony-stimulating factor, ANG2 angiopoietin 2, IL1RA interleukin-1 receptor antagonist, IL-6 interleukin-6, IL-8 interleukin-8
  2. aData are displayed as median (interquartile range)
  3. bExcluding subjects who received exogenous G-CSF within 30 days of enrollment
  4. cPlasma protein levels were compared between neutropenic and non-neutropenic using the Wilcoxon rank-sum test
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Critical Care

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