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Table 1 Patient characteristics by neutropenia statusa

From: Neutropenic sepsis is associated with distinct clinical and biological characteristics: a cohort study of severe sepsis

Patient characteristic

Non-neutropenic (n = 694)

Neutropenic (n = 100)

p b

Age

60 ± 16

58 ± 12

0.08

Male sex

387 (56 %)

66 (66 %)

0.06

Race

   

 White

380 (55 %)

73 (73 %)

<0.01

 Black

255 (37 %)

17 (17 %)

 

 Asian

19 (3 %)

0 (0 %)

 

 Other/unknown

40 (6 %)

10 (10 %)

 

APACHE III

74 (59–90)

87 (71–109)

<0.01

Documented bacteremia

182 (26 %)

43 (43 %)

<0.01

Source of infection

   

 Pulmonary

289 (42 %)

40 (40 %)

0.05

 Genitourinary

82 (12 %)

6 (6 %)

 

 Abdominal/gastrointestinal

93 (13 %)

15 (15 %)

 

 Head/neck

17 (2 %)

0 (0 %)

 

 Bloodc

58 (8 %)

15 (15 %)

 

 Skin/soft tissue/bone

40 (6 %)

2 (2 %)

 

 Gynecologic

2 (0 %)

0 (0 %)

 

 Unclear source

113 (16 %)

22 (22 %)

 

Shock at presentation

371 (53 %)

74 (74 %)

<0.01

Aminoglycoside exposure

182 (26 %)

65 (67 %)

<0.01

IV contrast exposure

143 (21 %)

23 (23 %)

0.97

ICU admitting source

   

 Emergency department

436 (63 %)

33 (33 %)

<0.01

 Hospital ward

200 (29 %)

64 (64 %)

 

 Other institution

58 (8 %)

3 (3 %)

 

Comorbidities

   

 Lymphoma

45 (6 %)

13 (13 %)

0.02

 Leukemia

33 (5 %)

52 (52 %)

<0.01

 Multiple myeloma

21 (3 %)

10 (10 %)

<0.01

 Solid malignancy

82 (12 %)

16 (16 %)

0.24

 Solid organ transplant

50 (7 %)

3 (3 %)

0.08

 AIDS

11 (2 %)

2 (2 %)

0.67

 Diabetes

225 (32 %)

19 (19 %)

<0.01

 Chronic renal disease

119 (17 %)

9 (9 %)

0.04

 Congestive heart failure

107 (15 %)

6 (6 %)

0.01

 Chronic liver disease

81 (12 %)

2 (2 %)

<0.01

Outcomes

   

 ARDSd

267 (38 %)

42 (42 %)

0.51

 AKId

263 (38 %)

58 (58 %)

<0.01

 30-day mortality

285 (41 %)

53 (53 %)

0.02

 60-day mortality

311 (45 %)

60 (60 %)

<0.01

  1. APACHE Acute Physiology and Chronic Health Evaluation, IV intravenous, ICU intensive care unit, AIDS acquired immune deficiency syndrome, ARDS acute respiratory distress syndrome, AKI acute kidney injury
  2. aData are shown as n (%) for categorical variables, mean ± standard deviation for normally distributed continuous variables, and median (interquartile range) for non-normally distributed continuous variables
  3. bNormally distributed continuous variables were compared using the Student’s t test, non-normally distributed continuous variables using the Wilcoxon rank-sum test, and categorical variables using a Pearson chi-square test or Fisher’s exact test
  4. cBlood source of infection included catheter-related blood stream infections, endocarditis, and thrombophlebitis
  5. dPatients were followed for the outcomes ARDS and AKI over the first 6 days of ICU admission