Absence of obvious link between supra-therapeutic serum levels of β lactams and clinical toxicity in ICU patients with acute renal failure treated with intermittent hemodialysis

Table 1 Antibiotics assessed, thresholds used, and trough serum levels (mg/l)

	Upper therapeutic trough level^a	Observed trough level median (interquartile range)
Piperacillin	20	77 (44–109)
Tazobactam	5	13 (6–20)
Cloxacillin	20	60 (35–103)
Amoxicillin	20	31 (19–42)
Imipenem	3	3 (1.1–4.2)
Clavulanate	0.5	2 (1.3–3.6)
Ceftazidim	20	71 (49–87)
Cefepime	10	27 (16–47)

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