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Table 1 TARGET initial proposed categorization and outcome scale

From: Individualizing endpoints in randomized clinical trials to better inform individual patient care: the TARGET proposal

Category Endpoint Measure
Younger than 65 years of age
 Paid employment (or unemployed but looking for work) Hours spent working Official Australian Labour Force Survey Questions on hours and nature of employment
 Unpaid caregiving (including parenting of children) Hours providing care Aging, Demographics, and Memory Study (ADAMS) Caregiving Provision Questions [34]
 Studying Hours studying or working Official Australian Labour Force Survey Questions on hours and nature of employment including hours spent studying
 Chronic disability Disability Living at Home or In Supportive Accommodation, and Independence in Activities of Daily Living (ADLs) [26] and Instrumental Activities of Daily Living (IADLs) [27]
 Environmentally disadvantaged Life satisfaction OECD Life Satisfaction Measure [35]
Aged 65 years and older
 Living fully independently Participation National Health & Aging Trends Study (NHATS) “Participation in Activities” Measures [25]
 Living independently with essential supports Disability Living at Home or In Supportive Accommodation, and Independence in Activities of Daily Living (ADLs) [26] and Instrumental ADLs (IADLs) [27]
 Living in supportive accommodation Disability Independence in Activities of Daily Living (ADLs) [26] and Instrumental Activities of Daily Living (IADLs) [27]
  1. TARGET’s proposed primary endpoint is 90-day mortality. All patients will complete an eq-5d-5l as part of their secondary endpoint assessment at day 180. In addition, the presented category-specific secondary endpoints will be assessed at day 180 after randomization