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Table 1 TARGET initial proposed categorization and outcome scale

From: Individualizing endpoints in randomized clinical trials to better inform individual patient care: the TARGET proposal

Category

Endpoint

Measure

Younger than 65 years of age

 Paid employment (or unemployed but looking for work)

Hours spent working

Official Australian Labour Force Survey Questions on hours and nature of employment

 Unpaid caregiving (including parenting of children)

Hours providing care

Aging, Demographics, and Memory Study (ADAMS) Caregiving Provision Questions [34]

 Studying

Hours studying or working

Official Australian Labour Force Survey Questions on hours and nature of employment including hours spent studying

 Chronic disability

Disability

Living at Home or In Supportive Accommodation, and Independence in Activities of Daily Living (ADLs) [26] and Instrumental Activities of Daily Living (IADLs) [27]

 Environmentally disadvantaged

Life satisfaction

OECD Life Satisfaction Measure [35]

Aged 65 years and older

 Living fully independently

Participation

National Health & Aging Trends Study (NHATS) “Participation in Activities” Measures [25]

 Living independently with essential supports

Disability

Living at Home or In Supportive Accommodation, and Independence in Activities of Daily Living (ADLs) [26] and Instrumental ADLs (IADLs) [27]

 Living in supportive accommodation

Disability

Independence in Activities of Daily Living (ADLs) [26] and Instrumental Activities of Daily Living (IADLs) [27]

  1. TARGET’s proposed primary endpoint is 90-day mortality. All patients will complete an eq-5d-5l as part of their secondary endpoint assessment at day 180. In addition, the presented category-specific secondary endpoints will be assessed at day 180 after randomization