From: Effects of dexmedetomidine and propofol on patient-ventilator interaction in difficult-to-wean, mechanically ventilated patients: a prospective, open-label, randomised, multicentre study
Cause of failure
Number of patients
Dexmedetomidine
Propofol
Respiratory rate >35 breaths/minute
2
4
PaO2ā<65 mmHg with FiO2ā<0.5 or SaO2ā<90 %
1
Evident respiratory distress
3
Coma, agitation or anxiety