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Table 3 Associations of biomarkers with acute kidney injury (any stage)

From: Association of markers of endothelial dysregulation Ang1 and Ang2 with acute kidney injury in critically ill patients

Biomarkers

Unadjusted RR

(95 % CI)

Adjusted RRa

(95 % CI)

APACHE III-adjusted RRb

(95 % CI)

IL6-adjusted RRc

(95 % CI)

Endothelial

 Ang-1

0.81 (0.74–0.88)***

0.81 (0.73–0.89)***

0.87 (0.80–0.95)**

0.85 (0.77–0.93)***

 Ang-2

1.22 (1.19–1.25)***

1.22 (1.18–1.26)***

1.16 (1.11–1.20)***

1.17 (1.13–1.22)***

 Ang-2/Ang-1

1.06 (1.03–1.08)***

1.06 (1.03–1.08)***

1.04 (1.02–1.06)***

1.05 (1.03–1.07)***

 sVCAM-1

1.09 (1.07–1.12)***

1.17 (1.12–1.21)***

1.13 (1.07–1.18)***

1.14 (1.10–1.19)***

Inflammatory

 IL-6

1.10 (1.07–1.14)***

1.10 (1.06–1.14)***

1.04 (1.00–1.08)

–

 IL-8

1.04 (1.01–1.07)*

1.04 (1.02–1.07)**

1.01 (0.98–1.03)

1.01 (0.98–1.04)

 IL-17

1.07 (1.05–1.10)***

1.06 (1.03–1.09)***

1.05 (1.02–1.08)**

1.04 (1.00–1.07)*

 G-CSF

1.06 (1.03–1.10)**

1.06 (1.03–1.10)**

1.01 (0.97–1.06)

0.99 (0.95–1.04)

 TNFR-1

1.21 (1.18–1.23)***

1.20 (1.17–1.22)***

1.16 (1.14–1.19)***

1.17 (1.15–1.20)***

  1. Relative risks (RR) presented per standard deviation of each biomarker
  2. aRelative risk regression adjusted for age, gender, sepsis, admitting service (ex: medical = 1, surgical = 0), body mass index, smoking status, diabetes mellitus, chronic renal insufficiency, and cirrhosis
  3. bAdjusted for APACHE III and covariates in a
  4. cAdjusted for Log2 (IL-6) concentration and covariates in a
  5. *p < 0.05; **p < 0.01; ***p < 0.001
  6. Ang angiopoietin, APACHE Acute Physiology, Age, Chronic Evaluation, CI confidence interval, G-CSF granulocyte colony-stimulating factor, IL interleukin, TNFR-1 tumor necrosis factor receptor 1, sVCAM-1 soluble vascular cell adhesion molecule-1
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Critical Care

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