Table 2 Plasma biomarkers according to AKI stage
Biomarker concentration | N | No AKI | AKI KDIGO stage | Â | ||
|---|---|---|---|---|---|---|
Stage 1 | Stage 2 | Stage 3 | ||||
Median (IQR) | Median (IQR) | Median (IQR) | Median (IQR) | p-value | ||
Endothelial | ||||||
 Ang-1, pg/mL | 935 | 6487.3 (3160.7–10,867.1) | 4424.7 (2084.6–8424.4) | 4393.3 (3458.2–13,075.6) | 3209.9 (1481.1, 6574.4) | <0.0001 |
 Ang-2, pg/mL | 944 | 9535.4 (5740.2–17,154.9) | 16283.0 (8491.6–32,757.3) | 16149.8 (9764.0–22,833.7) | 31227.4 (17316.6, 67176.1) | <0.0001 |
 Ang-2/Ang-1 | 935 | 1.4 (0.65–4.3) | 3.9 (1.8–13.3) | 2.7 (1.1–7.6) | 9.4 (3.7, 34.6) | <0.0001 |
 sVCAM-1, ng/mL | 944 | 497.4 (402.9–699.2) | 569.9 (446.2–803.2) | 708.6 (485.5–1058.6) | 828.6 (601.5, 1249.9) | <0.0001 |
Inflammatory | ||||||
 IL-6, pg/mL | 891 | 99.8 (46.5–233.4) | 151.4 (63.6–420.1) | 174.5 (82.3–461.5) | 171.8 (102.2, 400.9) | <0.0001 |
 IL-8, pg/mL | 891 | 11.0 (6.1–22.6) | 14.8 (7.7–35.0) | 16.4 (9.0–32.6) | 22.8 (11.4, 51.0) | <0.0001 |
 IL-17, pg/mL | 853 | 2.5 (1.1–7.2) | 3.8 (1.4–9.7) | 6.8 (1.7–11.6) | 4.6 (1.7, 12.1) | 0.0001 |
 G-CSF, pg/mL | 891 | 24.1 (14.2–45.8) | 30.3 (17.2–72.6) | 31.7 (17.6–66.9) | 31.3 (18.2, 70.6) | 0.0025 |
 TNFR-1, pg/mL | 891 | 6281.3 (4565.8–9790.6) | 9952.6 (6411.5–14,879.7) | 8910.5 (5198.26–19,151.48) | 31474.3 (18514.3, 47995.3) | <0.0001 |