TY - JOUR AU - Walter, Edward James AU - Hanna-Jumma, Sameer AU - Carraretto, Mike AU - Forni, Lui PY - 2016 DA - 2016/07/14 TI - The pathophysiological basis and consequences of fever JO - Critical Care SP - 200 VL - 20 IS - 1 AB - There are numerous causes of a raised core temperature. A fever occurring in sepsis may be associated with a survival benefit. However, this is not the case for non-infective triggers. Where heat generation exceeds heat loss and the core temperature rises above that set by the hypothalamus, a combination of cellular, local, organ-specific, and systemic effects occurs and puts the individual at risk of both short-term and long-term dysfunction which, if severe or sustained, may lead to death. This narrative review is part of a series that will outline the pathophysiology of pyrogenic and non-pyrogenic fever, concentrating primarily on the pathophysiology of non-septic causes. SN - 1364-8535 UR - https://doi.org/10.1186/s13054-016-1375-5 DO - 10.1186/s13054-016-1375-5 ID - Walter2016 ER -