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Table 4 Receiver operating characteristic curve analysis to determine the optimum cutoff value of the different biomarkers on day 0 for the prediction of infection (groups 2 + 3)

From: The intensive care infection score – a novel marker for the prediction of infection and its severity

  Parameters
Biomarkers AUROC (95 % CI) P Cutoff Sensitivity Specificity PPV NPV
WBC (109/L) 0.53 (0.46, 0.60) 0.38 12.9 0.54 0.54 0.55 0.54
CRP (mg/L) 0.70 (0.64, 0.76) <0.001 111 0.65 0.64 0.65 0.64
PCT (μg/L) 0.71 (0.66, 0.77) <0.001 1.41 0.65 0.66 0.66 0.65
ICIS 0.73 (0.67, 0.79) <0.001 5 0.66 0.71 0.70 0.67
  1. Abbreviations: AUROC area under the receiver operating characteristic curve, CI confidence interval, CRP C-reactive protein, ICIS intensive care infection score, PCT procalcitonin, PPV positive predictive value, NPV negative predictive value, WBC white blood cells. The AUROC for ICIS differed from that for WBC (P < 0.001)