Table 4 Vancomycin dosing and monitoring in patients with preserved renal function
From: Daily vancomycin dose requirements as a continuous infusion in obese versus non-obese SICU patients
Obese patients (n = 17) | Non-obese patients (n = 17) | P value | |
|---|---|---|---|
Goal concentration, 24 h, n | 15 | 14 | 0.628 |
Serum concentration, 24 h, mg/L | 20.6 (4.21) | 19.6 (4.41) | 0.494 |
Dose needed to achieve concentration of 20 mg/L, mg | 3774 (1498) | 4141 (1087) | 0.420 |
Dose needed to achieve concentration of 20 mg/L, mg/kg | 31.8 (14.5) | 56.9 (17.9) | <0.001 |
Loading dose, mg | 2985 (555) | 1941 (370) | <0.001 |
Loading dose, mg/kg | 24.6 (2.47) | 25.9 (1.88) | 0.09 |
Maintenance dose, mg | 3676 (1131) | 3882 (674) | 0.523 |
Maintenance dose, mg/kg | 30.8 (11.3) | 53.4 (13.7) | <0.001 |
AUC24 | 496 (101) | 471 (106) | 0.494 |
CLvanc, L/h | 7.86 (3.11) | 8.62 (2.26) | 0.420 |
CLvanc/CrCL | 0.79 (0.11) | 0.91 (0.21) | 0.049 |
CLvanc/ABW, L/h/kg | 0.09 (0.04) | 0.12 (0.04) | 0.0074 |
CLvanc/IBW, L/h/kg | 0.12 (0.05) | 0.12 (0.04) | 0.404 |
CLvanc/TBW, L/h/kg | 0.06 (0.03) | 0.12 (0.04) | 0.0001 |