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Table 4 Vancomycin dosing and monitoring in patients with preserved renal function

From: Daily vancomycin dose requirements as a continuous infusion in obese versus non-obese SICU patients

  Obese patients (n = 17) Non-obese patients (n = 17) P value
Goal concentration, 24 h, n 15 14 0.628
Serum concentration, 24 h, mg/L 20.6 (4.21) 19.6 (4.41) 0.494
Dose needed to achieve concentration of 20 mg/L, mg 3774 (1498) 4141 (1087) 0.420
Dose needed to achieve concentration of 20 mg/L, mg/kg 31.8 (14.5) 56.9 (17.9) <0.001
Loading dose, mg 2985 (555) 1941 (370) <0.001
Loading dose, mg/kg 24.6 (2.47) 25.9 (1.88) 0.09
Maintenance dose, mg 3676 (1131) 3882 (674) 0.523
Maintenance dose, mg/kg 30.8 (11.3) 53.4 (13.7) <0.001
AUC24 496 (101) 471 (106) 0.494
CLvanc, L/h 7.86 (3.11) 8.62 (2.26) 0.420
CLvanc/CrCL 0.79 (0.11) 0.91 (0.21) 0.049
CLvanc/ABW, L/h/kg 0.09 (0.04) 0.12 (0.04) 0.0074
CLvanc/IBW, L/h/kg 0.12 (0.05) 0.12 (0.04) 0.404
CLvanc/TBW, L/h/kg 0.06 (0.03) 0.12 (0.04) 0.0001
  1. Results are presented as mean (SD) unless stated otherwise. AUC24 area under the concentration curve 24 h, CLvanc continuous infusion vancomycin clearance, CrCL creatinine clearance, ABW adjusted body weight, IBW ideal body weight, TBW total body weight