Skip to main content

Table 3 Vancomycin dose and monitoring during CVVH

From: Daily vancomycin dose requirements as a continuous infusion in obese versus non-obese SICU patients

  Obese patients (n = 9) Non obese patients (n = 9) P value
Goal concentration, 24 h, n 9 9 1
Serum concentration, 24 h, mg/L 19.8 (3.05) 21.6 (3.02) 0.155
Dose needed to achieve concentration of 20 mg/L, mg 1426 (418) 1383 (282) 0.802
Dose needed to achieve concentration of 20 mg/L, mg/kg 13.8 (5.09) 19.9 (6.7) 0.004
Loading dose, mg 2722 (441) 1833 (280) <0.001
Loading dose, mg/kg 25.3 (0.774) 25.4 (1.49) 0.847
Maintenance dose, mg 1389 (397) 1500 (375) 0.550
Maintenance dose, mg/kg 13.3 (4.73) 21.7 (8.33) 0.01
AUC24 474 (73.2) 517 (48.6) 0.15
CLvanc, L/h 2.97 (0.87) 2.88 (0.60) 0.802
CLvanc/ABW, L/h/kg 0.04 (0.01) 0.04 (0.01) 0.34
CLvanc/IBW, L/h/kg 0.02 (0.02) 0.05 (0.01) 0.879
CLvanc/TBW, L/h/kg 0.03 (0.01) 0.04 (0.01) 0.044
  1. Results are presented as mean (SD) unless stated otherwise. CVVH continuous venovenous hemofiltration, AUC24 area under the concentration curve 24 h, CLvanc continuous infusion vancomycin cl, ABW adjusted body weight, IBW ideal body weight, TBW total body weight