Table 3 Vancomycin dose and monitoring during CVVH
From: Daily vancomycin dose requirements as a continuous infusion in obese versus non-obese SICU patients
Obese patients (n = 9) | Non obese patients (n = 9) | P value | |
|---|---|---|---|
Goal concentration, 24 h, n | 9 | 9 | 1 |
Serum concentration, 24 h, mg/L | 19.8 (3.05) | 21.6 (3.02) | 0.155 |
Dose needed to achieve concentration of 20 mg/L, mg | 1426 (418) | 1383 (282) | 0.802 |
Dose needed to achieve concentration of 20 mg/L, mg/kg | 13.8 (5.09) | 19.9 (6.7) | 0.004 |
Loading dose, mg | 2722 (441) | 1833 (280) | <0.001 |
Loading dose, mg/kg | 25.3 (0.774) | 25.4 (1.49) | 0.847 |
Maintenance dose, mg | 1389 (397) | 1500 (375) | 0.550 |
Maintenance dose, mg/kg | 13.3 (4.73) | 21.7 (8.33) | 0.01 |
AUC24 | 474 (73.2) | 517 (48.6) | 0.15 |
CLvanc, L/h | 2.97 (0.87) | 2.88 (0.60) | 0.802 |
CLvanc/ABW, L/h/kg | 0.04 (0.01) | 0.04 (0.01) | 0.34 |
CLvanc/IBW, L/h/kg | 0.02 (0.02) | 0.05 (0.01) | 0.879 |
CLvanc/TBW, L/h/kg | 0.03 (0.01) | 0.04 (0.01) | 0.044 |