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Table 2 Vancomycin dose and treatment

From: Daily vancomycin dose requirements as a continuous infusion in obese versus non-obese SICU patients

 

Obese (n = 26)

Non obese (n = 26)

P value

Loading dose, mg

2894 (525)

1923 (345)

<0.001

Loading dose, mg/kg

24.8 (2.05)

25.6 (1.66)

0.135

Maintenance dose, mg

2885 (1450)

3039 (1313)

0.69

Maintenance dose, mg/kg

24.8 (12.7)

41.9 (20)

<0.001

24 hour serum concentration, mg/L

20.3 (3.81)

20.0 (3.79)

0.777

CLvanc, L/h

6.16 (3.47)

6.64 (3.33)

0.617

Dose needed to achieve concentration of 20 mg/L, mg

2961 (1670)

3189 (1601)

0.617

Dose per ABW needed to achieve concentration of 20 mg/L, mg/kg

25.57 (14.8)

43.8 (23.5)

<0.01

AUC24

488. (91.5)

480.9 (91.04)

0.777

Achievement of therapeutic concentration at 24 hours, n

24

23

0.638

  1. Results are presented as mean (SD) or number. CLvanc continuous infusion vancomycin clearance, ABW adjusted body weight, AUC24 area under the concentration curve 24 h