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Table 2 Vancomycin dose and treatment

From: Daily vancomycin dose requirements as a continuous infusion in obese versus non-obese SICU patients

  Obese (n = 26) Non obese (n = 26) P value
Loading dose, mg 2894 (525) 1923 (345) <0.001
Loading dose, mg/kg 24.8 (2.05) 25.6 (1.66) 0.135
Maintenance dose, mg 2885 (1450) 3039 (1313) 0.69
Maintenance dose, mg/kg 24.8 (12.7) 41.9 (20) <0.001
24 hour serum concentration, mg/L 20.3 (3.81) 20.0 (3.79) 0.777
CLvanc, L/h 6.16 (3.47) 6.64 (3.33) 0.617
Dose needed to achieve concentration of 20 mg/L, mg 2961 (1670) 3189 (1601) 0.617
Dose per ABW needed to achieve concentration of 20 mg/L, mg/kg 25.57 (14.8) 43.8 (23.5) <0.01
AUC24 488. (91.5) 480.9 (91.04) 0.777
Achievement of therapeutic concentration at 24 hours, n 24 23 0.638
  1. Results are presented as mean (SD) or number. CLvanc continuous infusion vancomycin clearance, ABW adjusted body weight, AUC24 area under the concentration curve 24 h