From: Daily vancomycin dose requirements as a continuous infusion in obese versus non-obese SICU patients
Obese (n = 26) | Non obese (n = 26) | P value | |
---|---|---|---|
Loading dose, mg | 2894 (525) | 1923 (345) | <0.001 |
Loading dose, mg/kg | 24.8 (2.05) | 25.6 (1.66) | 0.135 |
Maintenance dose, mg | 2885 (1450) | 3039 (1313) | 0.69 |
Maintenance dose, mg/kg | 24.8 (12.7) | 41.9 (20) | <0.001 |
24 hour serum concentration, mg/L | 20.3 (3.81) | 20.0 (3.79) | 0.777 |
CLvanc, L/h | 6.16 (3.47) | 6.64 (3.33) | 0.617 |
Dose needed to achieve concentration of 20 mg/L, mg | 2961 (1670) | 3189 (1601) | 0.617 |
Dose per ABW needed to achieve concentration of 20 mg/L, mg/kg | 25.57 (14.8) | 43.8 (23.5) | <0.01 |
AUC24 | 488. (91.5) | 480.9 (91.04) | 0.777 |
Achievement of therapeutic concentration at 24 hours, n | 24 | 23 | 0.638 |