Table 1 Clinical and demographic characteristics of critically ill patients in the study
Characteristics | Clinical characteristics at D1 | Clinical characteristics at D3 | ||||
|---|---|---|---|---|---|---|
Total (n = 725) | D7 survivors (n = 616) | D7 non-survivors (n = 109) | Total (n = 515) | D28 survivors (n = 398) | D28 Non-survivors (n = 117) | |
Age, years | 65 [54–76] | 64 [52–75] | 71 [62–79]a | 64 [53–75] | 62 [51–74] | 73 [63–80]a |
Male sex | 450 (62.1 %) | 391 (63.5 %) | 59 (54.1 %) | 335 (65.0 %) | 252 (63.3 %) | 83 (70.9 %) |
SAPS II | 56 [42–69] | 53 [40–65] | 79 [65–97]a | 55 [42–67] | 52 [39–63] | 62 [51–73]a |
SOFA score at D1 | 9 [6–12] | 8 [6–11] | 13 [10–15]a | 6 [4–10] | 6 [3–8] | 9 [6–13]a |
Charlson comorbidity index score | 2 [0–3] | 2 [0–3] | 2 [1–4] | 1 [0–3] | 1 [0–3] | 2 [1–4]a |
Lactic acid, mmol/L | 2.2 [1.4–3.6] | 2.0 [1.3–3.1] | 4.2 [2.5–8.9]a | 1.4 [1.1–2.0] | 1.3 [1.1–1.8] | 1.8 [1.4–2.5]a |
Respiratory supportb | 581 (80.1 %) | 478 (77.6 %) | 103 (94.5 %)a | 402 (78.1 %) | 295 (74.1 %) | 107 (91.5 %)a |
Haemodynamic supportc | 489 (67.4 %) | 397 (64.4 %) | 92 (84.4 %)a | 231 (44.9 %) | 162 (40.7 %) | 69 (59.0 %)a |
Shock at D1d | 375 (51.7 %) | 288 (46.8) | 87 (79.8 %)a | 257 (49.9 %) | 193 (48.5 %) | 64 (54.7 %) |
Shock at D3d | 121 (23.5 %) | 76 (19.1 %) | 45 (38.5 %)a | |||
Septic shock | 279 (38.5 %) | 222 (36.0 %) | 57 (52.3 %)e | 192 (37.3 %) | 146 (36.7 %) | 46 (39.3 %) |
Diagnostic category | ||||||
Medical | 502 (69.2 %) | 421 (68.4 %) | 81 (74.3 %) | 357 (69.3 %) | 270 (67.8 %) | 87 (74.4 %) |
Planned surgery | 32 (4.4 %) | 31 (5.0 %) | 1 (0.9 %) | 24 (4.7 %) | 18 (4.5 %) | 6 (5.1 %) |
Urgent surgery | 191 (26.4 %) | 164 (26.6 %) | 27 (24.8 %) | 134 (26.0 %) | 110 (27.6 %) | 24 (20.5 %) |
Trauma | 67 (9.2 %) | 63 (10.2 %) | 4 (3.7 %) | 57 (11.1 %) | 54 (13.6 %) | 3 (2.6 %)e |
Sepsis | 506 (69.8 %) | 440 (71.4 %) | 66 (60.6 %) | 364 (70.7 %) | 280 (70.3 %) | 84 (71.8 %) |
Community-acquired | 323 (44.6 %) | 283 (45.9 %) | 40 (36.7 %) | 229 (44.5 %) | 183 (46.0 %) | 46 (39.3 %) |
Hospital-acquired | 183 (25.2 %) | 157 (25.5 %) | 26 (23.9 %) | 135 (26.2 %)e | 97 (24.4 %) | 38 (32.5 %) |
Site of infection | ||||||
Respiratory | 260 (35.9 %) | 229 (37.2 %) | 31 (28.4 %) | 197 (38.3 %) | 149 (37.4 %) | 48 (41.0 %) |
Abdominal | 113 (15.6 %) | 90 (14.6 %) | 23 (21.1 %) | 74 (14.4 %) | 50 (12.6 %) | 24 (20.5 %) |
Others | 133 (18.3 %) | 121 (19.6 %) | 12 (11.0 %) | 93 (18.1 %) | 81 (20.4 %) | 12 (10.3 %) |
Type of detection | ||||||
Clinical + imaging | 124 (24.5 %) | 108 (24.5 %) | 16 (24.2 %) | 96 (18.6 %) | 73 (18.3 %) | 23 (19.7 %) |
Clinical + surgery | 23 (4.5 %) | 17 (3.9 %) | 6 (9.1 %) | 14 (2.7 %) | 10 (2.5 %) | 4 (3.4 %) |
Microbiology | 339 (67.0 %) | 297 (67.5 %) | 42 (63.6 %) | 240 (46.6 %) | 186 (46.7 %) | 54 (46.2 %) |
Suspected | 20 (4.0 %) | 18 (4.0 %) | 2 (3.1 %) | 14 (2.7 %) | 11 (2.8 %) | 3 (2.6 %) |
Identified germ categories | ||||||
Gram-negative | 196 (57.8 %) | 172 (57.9 %) | 24 (57.1 %) | 134 (55.8 %) | 107 (57.5 %) | 27 (50.0 %) |
Gram-positive | 183 (54.0 %) | 162 (54.5 %) | 21 (50.0 %) | 140 (45.6 %) | 105 (56.5 %) | 35 (64.8 %) |
Fungi | 8 (2.4 %) | 8 (2.7 %) | 0 (0.0 %) | 6 (2.8 %) | 3 (1.8 %) | 3 (6.4 %) |
Plurimicrobial | 124 (36.6 %) | 112 (37.7 %) | 12 (28.6 %) | 95 (39.6 %) | 74 (39.8 %) | 21 (38.9 %) |
Anti-infectious treatment | ||||||
Adequacy | 487 (96.4 %) | 429 (97.5 %) | 58 (89.2 %) | 356 (97.8 %) | 274 (97.9 %) | 82 (97.6 %) |
To the antibiogram | 291 (59.8 %) | 258 (60.1 %) | 33 (56.9 %) | 211 (59.3 %) | 163 (59.5 %) | 48 (58.5 %) |
To the protocol | 196 (40.3 %) | 171 (39.9 %) | 25 (43.1 %) | 145 (40.7 %) | 111 (40.5 %) | 34 (41.5 %) |