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Table 5 Likelihood ratios (LR) (95 % CI) and odds

From: Adrenomedullin and endothelin-1 are associated with myocardial injury and death in septic shock patients

  Myocardial injury Mortality at 28 days Mortality at 7 days
  LR+ Given positive test pre/posttest odds LR- Given negative test pre/posttest odds LR+ Given positive test pre/posttest odds LR- Given negative test pre/posttest odds LR+ Given positive test pre/posttest odds LR- Given negative test pre/posttest odds
MR-proADM 3.03 1.24/3.76 0.52 1.24/0.64 2.03 0.39/0.79 0.33 0.39/0.13 4.3 0.23/0.99 0.13 0.23/0.03
(1.18, 7.76)   (0.32, 0.86)   (1.269, 3.236)   (0.116, 0.939)   (2.32, 7.97)   (0.02, 0.82)  
CT-proET-1 3.39 1.24/4.20 0.25 1.24/0.31 1.79 0.39/0.70 0.46 0.39/0.14 2.01 0.23/0.46 0.46 0.23/0.11
(1.54, -7.46)   (0.11, 0.57)   (1.158, 2.762)   (0.233, 0.987)   (1.13, 3.57)   (0.17, 1.22)  
hsTNT - - - - 3.20 0.35/1.12 0.39 0.35/0.14 2.86 0.19/0.54 0.34 0.19/0.07
     (1.570, 6.529)   (0.171, 0.903)   (1.50, 5.47)   (0.10, 1.14)  
MR-proADM and CT-proET-1 12 1.24/14.9 0.44 1.24/0.55 2.14 0.39/0.84 0.27 0.39/0.10 5.02 0.23/1.15 0.17 0.23/0.04
(1.74, 84)   (0.28, 0.70)   (1.25, 3.67)   (0.07, 1.01)   (1.95, 9.47)   (0.02, 1.04)  
MR-proADM, CT-proET-1 and hsTNT - - - - 19.92 0.35/6.97 NA* NA* 13.13 0.19/2.49 NA* NA*
     (2.70, 146.88)     (3.06, 56.24)    
  1. MR-proADM mid-regional pro-adrenomedullin, CT-proET-1 C-terminal pro-endothelin-1, hsTNT high-sensitivity troponin T. NA, not analyzed. *It was not possible to calculate the LR- for all three biomarkers combined, because none of the patients with low values died
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