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Table 5 Likelihood ratios (LR) (95 % CI) and odds

From: Adrenomedullin and endothelin-1 are associated with myocardial injury and death in septic shock patients

 

Myocardial injury

Mortality at 28 days

Mortality at 7 days

 

LR+

Given positive test pre/posttest odds

LR-

Given negative test pre/posttest odds

LR+

Given positive test pre/posttest odds

LR-

Given negative test pre/posttest odds

LR+

Given positive test pre/posttest odds

LR-

Given negative test pre/posttest odds

MR-proADM

3.03

1.24/3.76

0.52

1.24/0.64

2.03

0.39/0.79

0.33

0.39/0.13

4.3

0.23/0.99

0.13

0.23/0.03

(1.18, 7.76)

 

(0.32, 0.86)

 

(1.269, 3.236)

 

(0.116, 0.939)

 

(2.32, 7.97)

 

(0.02, 0.82)

 

CT-proET-1

3.39

1.24/4.20

0.25

1.24/0.31

1.79

0.39/0.70

0.46

0.39/0.14

2.01

0.23/0.46

0.46

0.23/0.11

(1.54, -7.46)

 

(0.11, 0.57)

 

(1.158, 2.762)

 

(0.233, 0.987)

 

(1.13, 3.57)

 

(0.17, 1.22)

 

hsTNT

-

-

-

-

3.20

0.35/1.12

0.39

0.35/0.14

2.86

0.19/0.54

0.34

0.19/0.07

    

(1.570, 6.529)

 

(0.171, 0.903)

 

(1.50, 5.47)

 

(0.10, 1.14)

 

MR-proADM and CT-proET-1

12

1.24/14.9

0.44

1.24/0.55

2.14

0.39/0.84

0.27

0.39/0.10

5.02

0.23/1.15

0.17

0.23/0.04

(1.74, 84)

 

(0.28, 0.70)

 

(1.25, 3.67)

 

(0.07, 1.01)

 

(1.95, 9.47)

 

(0.02, 1.04)

 

MR-proADM, CT-proET-1 and hsTNT

-

-

-

-

19.92

0.35/6.97

NA*

NA*

13.13

0.19/2.49

NA*

NA*

    

(2.70, 146.88)

   

(3.06, 56.24)

   
  1. MR-proADM mid-regional pro-adrenomedullin, CT-proET-1 C-terminal pro-endothelin-1, hsTNT high-sensitivity troponin T. NA, not analyzed. *It was not possible to calculate the LR- for all three biomarkers combined, because none of the patients with low values died