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Table 2 Studies with multivariate analyses for mortality

From: Increased body mass index and adjusted mortality in ICU patients with sepsis or septic shock: a systematic review and meta-analysis

      

Baseline study characteristics

Author (Y) (Total patients)

BMI studied (kg/m2)

Non-survivor/total

BMI

Age

Gender

Comorbid illnesses

Severity of acute illness

Other

Studies of sepsis, severe sepsis, and septic shock

Sakr [31] (2008) (n = 431)

Underweight (<18.5)

NR/17c

NR

NR

NR

NR

SAPS II

NR

Normal (18.5–24.9)

NR/179c

Overweight (25–29.9)

NR/148c

Obese (30–39.9)

NR/76c

Very obese (>40)

NR/11c

Wurzinger [15] (2010) (n = 301)

Underweight (<18.5)

3/15

Yesd

Yes

Yes

COPD, HTN, DM, CRI, HO, heart disease

SAPS IId

Admission year, origin of sepsis

Normal (18.5–24.9)

28/125

Overweight (25–29.9)

15/95

Obese (30–39.9)

4/66

Adamzik [32] (2011) (n = 125)

Continuous BMIa

NR

Yes

Yes

Yes

Hemofiltration/dialysis

SAPS II, SOFA score

IL-6d, aquaporin 5 genotyped, CRP, serum aldosterone, plasma angiotensin II, procalcitonin

Arabi [17] (2013) (n = 2882)

Underweight (<18.5)b

121/196

Yes

Yes

Yes

ID, HF, COPD, DM, Elective surgery

APACHE II

Type and source of bacterial infection, type of sepsis interventions

Normal (18.5–24.9)

580/1020

Overweight (25–29.9)b

444/816

Obese (30–39.9)

349/680

Morbidly obese (>40)

76/170

Wacharasint [16] (2013) (n = 730)

Continuous BMIa

NR

Yesd

NR

Yes

DM

APACHE IId

Lung infection, fungal infection

Sakr [33] (2015) (n = 2696)

Underweight (<18.5)

NR

Yes

Yes

Yes

Comorbiditiese

SAPS II, SOFA score

Type and source of admission, need for mechanical ventilation or renal replacement therapy at ICU admission, type of hospital, ICU specialty, total number of ICU patients in 2011, number of staffed ICU beds, gross national income of country

Normal (18.5–24.9)

NR

Overweight (25–29.9)

NR

Obese (30–39.9)

NR

Very obese (>40)

NR

  1. BMI body mass index, NR not reported, SAPS Simplified Acute Physiology Score, COPD chronic obstructive pulmonary disease, HTN arterial hypertension, DM diabetes mellitus, CRI chronic renal insufficiency, HO hematologic/oncologic disease, SOFA Sepsis-related Organ Failure Assessment score, IL-6 interleukin-6, CRP C-reactive protein, ID immunodeficiency, HF heart failure, cancer, heart disease, APACHE Acute Physiology and Chronic Health Evaluation, ICU intensive care unit
  2. aContinuous BMI: regression model used with body mass index as a continuous variable
  3. bAdjusted odds ratio for mortality not provided by study for this BMI category
  4. cNumerator not reported
  5. dIndependently associated with mortality in multivariate analysis
  6. eComorbidities not listed in multivariate analysis
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