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Table 1 Demographics and baseline data

From: The Dose Response Multicentre Investigation on Fluid Assessment (DoReMIFA) in critically ill patients

Patient characteristics

All patients

(n = 1734)

Patients without AKI

(n = 991) 57.2 %

Patients with AKIb

(n = 743) 42.8 %

p value

Male gender (%)

65.34 %

64.08 %

67.03 %

0.2016

Age in years, mean ± SD

59.23 ± 15.19

57.56 ± 15.48

61.46 ± 14.50

<0.0001

Weight in kg, mean ± SD

75.16 ± 16.89

73.49 ± 15.69

77.38 ± 18.15

<0.0001

 - % measured weight

67.99 %

66.20 %

70.39 %

0.0639

Creatinine reference in mg/dl, mean ± SD

1.13 ± 1.02

1.00 ± 0.68

1.29 ± 1.33

<0.0001

 - % measured Cr

63.78 %

61.96 %

66.22 %

Creatinine at baseline in mg/dl

1.14 ± 1.02

1.01 ± 0.78

1.31 ± 1.26

<0.0001

Reason for admission (%)

   

<0.0001

 - Cardiovascular

37.60

36.43

39.17

 - Respiratory

11.53

10.60

12.79

 - Gastrointestinal

9.46

8.27

11.04

 - Trauma

10.32

13.42

6.19

 - Transplant

1.44

0.81

2.29

 - Infections

7.73

5.15

11.17

 - Neurologic

12.92

17.56

6.73

 - Other

8.82

7.77

10.23

Severity of illness scores (mean ± SD)

 - SAPS II

39.12 ± 16.99

35.04 ± 15.39

44.56 ± 17.50

<0.0001

 - APACHE II

17.11 ± 7.66

15.14 ± 6.74

19.74 ± 8.03

<0.0001

 - SOFA

6.63 ± 3.66

5.49 ± 3.16

8.15 ± 3.74

<0.0001

Renal pathologies (%)

 - Proteinuria/hematuria

0.98

0.20

2.02

<0.0001

 - CKD not on dialysis

8.07

4.94

12.25

 - no CKD

65.22

69.83

59.08

 - renal transplant

1.15

0.40

2.15

 - no data available

24.57

24.62

24.50

Comorbidities (%)

    

 - diabetes

21.40

17.05

27.19

<0.0001

 - cardiovascular

45.79

43.29

49.13

0.0208

 - hypertension

46.94

43.19

51.95

0.0004

Use of NSAIDs (%)

5.59

5.05

6.33

0.2510

Use of ACE-I/ARB (%)

13.09

13.52

12.52

0.5393

Mechanical ventilation (%)

 - on admission

69.61

67.00

73.08

0.0125

 - during ICU stay

83.45

79.31

88.96

<.0001

Respiratory support on admission (%)

   

0.0038

 - none

20.88

22.81

18.30

 - non-invasive ventilation

9.63

10.60

8.34

 - invasive ventilation

59.98

56.41

64.74

Days on mechanical ventilation

 - mean ± SD

6.35 ± 9.18

4.45 ± 6.53

8.87 ± 11.35

<0.0001

 - median [IQR]

3.0 [1.0;8.0]

2.0 [1.0; 5.0]

5.0 [2.0; 13.0]

Sepsisa (%)

 - on admission

23.35

17.25

31.36

<0.0001

 - on first AKI day (or admission)

23.24

17.25

31.22

<0.0001

 - during ICU stay

34.14

25.43

45.76

<0.0001

Severity of sepsis on admission (%)

 - SIRS

13.01

11.20

15.34

<0.0001

 - sepsis

7.11

7.16

7.00

 - severe sepsis

5.72

4.14

7.81

 - septic shock

10.52

5.95

16.55

RRT in ICU (%)

11.42 %

1.51 %

24.63 %

<0.0001

Death in ICU (%)

12.75 %

5.55 %

22.34 %

<0.0001

Length of ICU stay (days)

 - mean ± SD

9.54 ± 10.19

7.64 ± 7.71

12.07 ± 12.32

<0.0001

 - median [IQR]

6.0 [3.0; 12.0]

5.0 [3.0; 9.0]

8.0 [4.0; 15.0]

Renal status at ICU discharge (%)

 - Dialysis dependent

7.15

1.11

15.21

<0.0001

 - Dialysis independent but renal function not returned to baseline

16.96

4.14

34.05

 - renal function returned to baseline

7.67

4.04

12.52

 - normal renal function

68.22

90.72

38.22

  1. Measured weight: patient’s weight as measured on ICU admission (not estimated). Measured Cr: creatinine from laboratory and not estimated with MDRD
  2. Abbreviations: AKI acute kidney injury, SD standard deviation, Cr creatinine, SAPS II Simplified Acute Physiology Score II, APACHE II Acute Physiology and Chronic Health Evaluation II, SOFA Sequential Organ Failure Assessment, CKD chronic kidney disease, NSAID non-steroidal anti-inflammatory drug, ACE-I ACE inhibitor, ARB angiotensin receptor blocker, ICU intensive care unit, IQR interquartile range, SIRS Systemic Inflammatory Response Syndrome, RRT renal replacement therapy
  3. aSepsis includes: sepsis, severe sepsis, and septic shock
  4. bAll AKI patients (AKI-RRT included)
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Critical Care

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