Table 3 Patient characteristics at time of ventilator-associated pneumonia diagnosis
All patients (n = 71) | Nongradual VAP (n = 28) | Gradual VAP (n = 43) | p Value | |
|---|---|---|---|---|
MV duration before VAP, days | 7 [4.5–10.5] | 4.5 [3–9] | 8 [6.5–11.5] | 0.002 |
Early VAP | 21 (29 %) | 16 (57 %) | 5 (12 %) | <0.001 |
SOFA score | 5.5 [8–11.5] | 10 [8–12] | 7 [5–11] | 0.142 |
mCPIS score | 7 [6–8] | 7 [6–8] | 7 [6–8] | 0.908 |
PaO2/FiO2 | 197 [137–247] | 200 [160–282] | 180 [130–226] | 0.119 |
Temperature, °C | 38 [37–38.7] | 38 [36.7–38.6] | 38 [37–38.7] | 0.928 |
Leukocytes, cells/mm3 | 12250 [8050–17,400] | 12,000 [9100–16,800] | 12,400 [7500–17,500] | 0.930 |
CRP (mg/L) | 151 [90–315] | 200 [100–340] | 132 [73.5–265] | 0.301 |
PCT (ng/ml) | 1.4 [0.5–4.3] | 1.4 [0.5–6.08] | 1.4 [0.5–4.1] | 0.961 |
Etiology | ||||
Nonfermenting GNB | 42 (52 %) | 17 (61 %) | 25 (58 %) | 0.829 |
Enterobacteriaceae | 14 (20 %) | 6 (21 %) | 8 (19 %) | 0.770 |
Staphylococcus aureus | 8 (11 %) | 2 (7 %) | 6 (14 %) | 0.315 |
Haemophilus influenzae | 5 (7 %) | 2 (7 %) | 3 (7 %) | 0.661 |
Streptococcus | 1 (1 %) | 0 | 1 (2 %) | 0.606 |
Aspergillus | 1 (1 %) | 1 (3 %) | 0 | 0.394 |
Treatment failure (72 h) | 39 (55 %) | 17 (61 %) | 22 (51 %) | 0.442 |
Microbial persistence (72 h) | 43 (61 %) | 16 (57 %) | 27 (63 %) | 0.361 |
Relapse | 8 (11 %) | 3 (11 %) | 5 (11 %) | 0.121 |
ICU stay, days,) | 19 [13–29] | 16 [12–28.5] | 20.5 [14–29] | 0.346 |
Hospital stay, days | 24 [12–51] | 19.5 [9–42] | 29 [16–57] | 0.054 |
Days of MV | 13 [8–18] | 13.5 [8.5–19.5] | 12.5 [8–17] | 0.679 |
28-day mortality | 43 (61 %) | 18 (64 %) | 25 (58 %) | 0.605 |