Demographics | Controls | No MODS | MODS | p value |
---|---|---|---|---|
n | 8 | 19 | 11 | - |
% male | 100 | 83 | 77 | 0.38 |
Age‡ | 32 (26–35) | 35 (27–44) | 34 (27–52) | 0.71 |
ISS‡ | 1 (1–2) | 10 (9–18) | 33 (25–50) | <0.01 |
Base deficit (mmol/L)‡ | −1.9 (−2.3 to −1.0) | −0.5 (−1.4 to −1.6) | 3.8 (2.4–7.9) | <0.01 |
Time of sample from injury (mins)‡ | 66 (60–78) | 67 (54–75) | 85 (70–95) | 0.09 |
CSL pre-draw (ml)‡ | 0 (0) | 0 (0) | 500 (0–500) | <0.01 |
SBP on arrival (mmHg)‡ | 140 (135–149) | 139 (131–145) | 109 (96–125) | <0.01 |
Hospital length of stay (days)‡ | 2 (1–3) | 7 (3–14) | 20 (8–39) | 0.07 |
ICU length of stay (days)‡ | 0 (0) | 0 (0) | 8 (2–13) | <0.01 |
28-day mortality % (n) | 0 (0) | 0 (0) | 31 | <0.01 |
Percentage† | ||||
Lymphocytes | 18 (12–24) | 18 (12–23) | 17 (8–27) | 0.95 |
Total NK cells | 16 (7–24) | 14 (11–17) | 23 (16–29) | 0.02 |
NK bright | 0.6 (0.2–1.0) | 1.3 (0.4–2.2) | 0.8 (0.4–1.1) | 0.12 |
NK dim | 15 (7–23) | 13 (10–16) | 22 (16–28) | <0.01 |
Gamma delta high | 0.7 (0.4–1.0) | 1.4 (0.2–2.5) | 1.8 (0.0–3.9) | 0.86 |
Gamma delta low | 2.1 (1.2–2.9) | 4.0 (2.5–5.5) | 0.9 (0.5–1.4) | <0.01 |
T helpers | 32 (26–38) | 32 (28–36) | 35 (29–41) | 0.28 |
Cytotoxic T cells | 23 (18–27) | 28 (23–33) | 21 (17–25) | 0.16 |
Cell count × 109/L† | ||||
Lymphocytes | 2.0 (1.3–3.2) | 1.4 (0.4–5.1) | 2.5 (1.7–3.6) | 0.80 |
Total NK cells | 0.2 (0.1–0.6) | 0.5 (0.2–0.7) | 0.6 (0.2–0.9) | 0.14 |
NK bright | 0.01 (0.01–0.02) | 0.03 (0.01–0.05) | 0.02 (0.01–0.03) | 0.20 |
NK dim | 0.2 (0.1–0.5) | 0.4 (0.2–0.6) | 0.5 (0.2–0.8) | 0.12 |
Gamma delta high | 0.01 (0.01–0.03) | 0.04 (0.00–0.09) | 0.06 (0.00–0.16) | 0.73 |
Gamma delta low | 0.03 (0.01–0.08) | 0.09 (0.06–0.12) | 0.02 (0.01–0.03) | <0.01 |
T helpers | 0.6 (0.4–0.8) | 0.9 (0.7–1.1) | 0.7 (0.5–0.9) | 0.08 |
Cytotoxic T cells | 0.4 (0.3–0.7) | 0.8 (0.6–1.0) | 0.5 (0.3–0.7) | 0.46 |