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Table 1 Demographics of flow cytometry cohort

From: Early changes within the lymphocyte population are associated with the development of multiple organ dysfunction syndrome in trauma patients

Demographics Controls No MODS MODS p value
n 8 19 11 -
% male 100 83 77 0.38
Age 32 (26–35) 35 (27–44) 34 (27–52) 0.71
ISS 1 (1–2) 10 (9–18) 33 (25–50) <0.01
Base deficit (mmol/L) −1.9 (−2.3 to −1.0) −0.5 (−1.4 to −1.6) 3.8 (2.4–7.9) <0.01
Time of sample from injury (mins) 66 (60–78) 67 (54–75) 85 (70–95) 0.09
CSL pre-draw (ml) 0 (0) 0 (0) 500 (0–500) <0.01
SBP on arrival (mmHg) 140 (135–149) 139 (131–145) 109 (96–125) <0.01
Hospital length of stay (days) 2 (1–3) 7 (3–14) 20 (8–39) 0.07
ICU length of stay (days) 0 (0) 0 (0) 8 (2–13) <0.01
28-day mortality % (n) 0 (0) 0 (0) 31 <0.01
Percentage     
Lymphocytes 18 (12–24) 18 (12–23) 17 (8–27) 0.95
Total NK cells 16 (7–24) 14 (11–17) 23 (16–29) 0.02
NK bright 0.6 (0.2–1.0) 1.3 (0.4–2.2) 0.8 (0.4–1.1) 0.12
NK dim 15 (7–23) 13 (10–16) 22 (16–28) <0.01
Gamma delta high 0.7 (0.4–1.0) 1.4 (0.2–2.5) 1.8 (0.0–3.9) 0.86
Gamma delta low 2.1 (1.2–2.9) 4.0 (2.5–5.5) 0.9 (0.5–1.4) <0.01
T helpers 32 (26–38) 32 (28–36) 35 (29–41) 0.28
Cytotoxic T cells 23 (18–27) 28 (23–33) 21 (17–25) 0.16
Cell count × 109/L     
Lymphocytes 2.0 (1.3–3.2) 1.4 (0.4–5.1) 2.5 (1.7–3.6) 0.80
Total NK cells 0.2 (0.1–0.6) 0.5 (0.2–0.7) 0.6 (0.2–0.9) 0.14
NK bright 0.01 (0.01–0.02) 0.03 (0.01–0.05) 0.02 (0.01–0.03) 0.20
NK dim 0.2 (0.1–0.5) 0.4 (0.2–0.6) 0.5 (0.2–0.8) 0.12
Gamma delta high 0.01 (0.01–0.03) 0.04 (0.00–0.09) 0.06 (0.00–0.16) 0.73
Gamma delta low 0.03 (0.01–0.08) 0.09 (0.06–0.12) 0.02 (0.01–0.03) <0.01
T helpers 0.6 (0.4–0.8) 0.9 (0.7–1.1) 0.7 (0.5–0.9) 0.08
Cytotoxic T cells 0.4 (0.3–0.7) 0.8 (0.6–1.0) 0.5 (0.3–0.7) 0.46
  1. p values compare no MODS vs MODS, using Student’s t test
  2. MODS multiple organ dysfunction syndrome, ISS Injury Severity Score, CSL intravenous crystalloid fluid, SBP systolic blood pressure, ICU intensive care unit, NK natural killer
  3. Median (interquartile range)
  4. Mean (95 % confidence interval)