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Table 1 Patient characteristics

From: Inflammasome and toll-like receptor signaling in human monocytes after successful cardiopulmonary resuscitation

  CPR group (n = 51) CAD group (n = 19) P value
Age (years) 66.49 ± 11.53 68.89 ± 11.60 0.441
Gender male:female 39:12 15:4 1.0
CPR scene    
 OHCA 41 (80 %) N/A  
 IHCA 10 (20 %) N/A  
Etiology of cardiac arrest    
 Cardiac 32 (63 %) N/A  
 Non-cardiac 13 (25 %) N/A  
 Unknown 6 (12 %) N/A  
Initial rhythm    
 VT/VF 29 (57 %) N/A  
 Asystole/PEA 22 (43 %) N/A  
Time from collapse to CPR (minutes) 2.43 ± 3.88 N/A  
Time from collapse to ROSC (minutes) 29.84 ± 19.11 N/A  
Interventions    
 Therapeutic hypothermia performed 50 (98 %) N/A  
 Coronary angiography <12 h prior to study enrollment 39 (76 %) 8 (42 %) 0.01
 PCI <12 h prior to study enrollment 23 (45 %) 8 (42 %) 1.0
Consecutive organ failure    
 Acute heart failure 19 (37 %) 0 (0 %) 0.002
 Acute respiratory failure 7 (14 %) 0 (0 %) 0.177
 Acute liver failure 0 (0 %) 0 (0 %) N/A
 Acute renal failure 16 (31 %) 0 (0 %) 0.004
Sequential organ failure assessment (SOFA) score    
 Day 1 after ROSC 10.53 ± 1.75 N/A  
 Day 2 after ROSC 10.83 ± 1.63 N/A  
 Day 3 after ROSC 10.85 ± 1.83 N/A  
Medical history    
 Coronary artery disease 34 (67 %) 19 (100 %) 0.003
 Peripheral artery disease 3 (6 %) 1 (5 %) 1.0
 Chronic heart failure 9 (18 %) 3 (16 %) 1.0
 Pulmonary hypertension 6 (12 %) 0 (0 %) 0.180
 Chronic lung disease 14 (27 %) 1 (5 %) 0.052
 Chronic liver disease 0 (0 %) 0 (0 %) N/A
 Chronic kidney disease 6 (12 %) 5 (26 %) 0.155
Cardiovascular risk factors    
 Hypertension 29 (57 %) 15 (79 %) 0.104
 Diabetes 13 (25 %) 6 (32 %) 0.763
 Dyslipidemia 16 (31 %) 13 (68 %) 0.007
 Smoking 19 (37 %) 12 (63 %) 0.063
 Overweight 14 (27 %) 7 (37 %) 0.559
  1. Acute heart failure was defined by clinical signs of cardiac decompensation or cardiogenic shock. Acute renal failure was defined as an increase in serum creatinine ≥0.3 mg/dl or ≥1.5-fold increase from baseline creatinine within the first 48 h. Acute liver failure was defined as an increase in total bilirubin serum levels and an increase in the international normalized ratio (INR) value above the normal values of our central laboratory. Acute respiratory failure was defined as an oxygenation index (ratio of PaO2 (mmHg) and FiO2 (%)) ≤200 mmHg
  2. CPR cardiopulmonary resuscitation, CAD coronary artery disease, OHCA out-of-hospital cardiac arrest, IHCA in-hospital cardiac arrest, VT ventricular tachycardia, VF ventricular fibrillation, PEA pulseless electrical activity, ROSC return of spontaneous circulation, PCI percutaneous coronary intervention, N/A not applicable