A prospective multicenter cohort study of frailty in younger critically ill patients

Table 2 Multivariable analysis of factors associated with prehospital frailty among patients younger than 65 years old

Variable	Adjusted OR (95 % CI)	p Value	% contribution
Sex			3.8
Male	1
Female	2.01 (0.87–4.66)	0.103
Elixhauser comorbidity score, mean ± SD	0.96 (0.91–1.02)	0.213	1.6
Rheumatoid/CTD	6.00 (2.12–17.0)	0.001	19.7
Heart failure	3.28 (0.78–13.7)	0.104	1.8
Prehospital residence			49.3
At home (independent)	1
At home (with help)/other	4.40 (1.75–11.1)	0.002
On disability	2.11 (0.83–5.35)	0.117	4.1
Managing own finances (independent)	0.24 (0.05–1.24)	0.088	3.5
Never married	0.23 (0.03–1.56)	0.133	2.8
Education			1.7
Less than high school	1
High school	0.76 (0.23–2.50)	0.653
Higher-level degree	0.53 (0.16–1.75)	0.296
Prescription medications, n, mean ± SD	1.01 (0.93–1.10)	0.748	0.1
Prior hospitalization	3.29 (1.34–8.10)	0.010	11.7

CTD connective tissue disease
The overall model is significant (likelihood ratio χ₁₂ ² = 78.73 with p < 0.0001) with good discriminatory ability (c-statistic 0.85) and goodness of fit (calibration, Brier score 0.12; Hosmer-Lemeshow χ₈ ² = 10.37 with p = 0.24). In sensitivity analyses, age, surgical status, and sepsis were also included in the multivariable model. These did not translate into significant changes across any covariates or percentage contribution to the model.

ISSN: 1364-8535