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Table 5 Multivariate logistic regression model with mortality at 60 days as the outcome and genotypes as predictors

From: Association of common genetic variation in the protein C pathway genes with clinical outcomes in acute respiratory distress syndrome

Predictors OR 95 % CI p Value
Endothelial protein C receptor (EPCR) SNPs
 rs9574, GC/GG vs. CC 2.8 1.1–7.3 0.04
 Age, years 1.03 1.01–1.05 <0.003
 APACHE III score 1.04 1.02–1.05 <0.001
 Sepsis, yes/no 1.3 0.6–2.7 0.6
 PaO2/FiO2 1.001 0.99–1.01 0.7
 Fluid strategy, liberal vs. conservative 1.5 0.8–2.8 0.24
Thrombomodulin (TM) SNPs
 rs3176123, CC vs. AA/AC 6.3 1.6–24.8 0.008
 rs1042580, GG vs. AA/AG 2.8 1.2–6.1 <0.02
 Age, years 1.02 1.00–1.05 0.03
 APACHE III score 1.04 1.02–1.05 <0.001
 Sepsis, yes/no 1.2 0.6–2.3 0.55
 PaO2/FiO2 1.001 0.99–1.01 0.15
 Fluid strategy, liberal vs. conservative 1.2 0.6–2.3 0.88
Thrombomodulin, endothelial protein C receptor and protein C SNPs (combined model)
 THBD rs3176123 6.1 1.6–24 0.01
 THBD rs1042580 2.6 1.1–6.1 0.03
 EPCR rs9574 2.9 1.08–7.9 0.03
 Age, years 1.03 1.0–1.05 <0.02
 APACHE III score 1.04 1.01–1.05 <0.001
 Sepsis, yes/no 1.3 0.6–2.7 0.53
 PaO2/FiO2 1.00 0.99–1.01 0.71
 Fluid strategy, liberal vs. conservative 1.3 0.6–2.6 0.44
  1. APACHE Acute Physiology and Chronic Health Evaluation, EPCR endothelial protein C receptor, FiO 2 fraction of inspired oxygen, PaO 2 partial pressure of arterial oxygen, SNP single-nucleotide polymorphism, THBD thrombomodulin gene, TM thrombomodulin
  2. Models are adjusted for age, APACHE III score, presence of sepsis, baseline PaO2/FiO2 ratio, and allocation to fluid management arm