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Table 5 Multivariate logistic regression model with mortality at 60 days as the outcome and genotypes as predictors

From: Association of common genetic variation in the protein C pathway genes with clinical outcomes in acute respiratory distress syndrome

Predictors

OR

95 % CI

p Value

Endothelial protein C receptor (EPCR) SNPs

 rs9574, GC/GG vs. CC

2.8

1.1–7.3

0.04

 Age, years

1.03

1.01–1.05

<0.003

 APACHE III score

1.04

1.02–1.05

<0.001

 Sepsis, yes/no

1.3

0.6–2.7

0.6

 PaO2/FiO2

1.001

0.99–1.01

0.7

 Fluid strategy, liberal vs. conservative

1.5

0.8–2.8

0.24

Thrombomodulin (TM) SNPs

 rs3176123, CC vs. AA/AC

6.3

1.6–24.8

0.008

 rs1042580, GG vs. AA/AG

2.8

1.2–6.1

<0.02

 Age, years

1.02

1.00–1.05

0.03

 APACHE III score

1.04

1.02–1.05

<0.001

 Sepsis, yes/no

1.2

0.6–2.3

0.55

 PaO2/FiO2

1.001

0.99–1.01

0.15

 Fluid strategy, liberal vs. conservative

1.2

0.6–2.3

0.88

Thrombomodulin, endothelial protein C receptor and protein C SNPs (combined model)

 THBD rs3176123

6.1

1.6–24

0.01

 THBD rs1042580

2.6

1.1–6.1

0.03

 EPCR rs9574

2.9

1.08–7.9

0.03

 Age, years

1.03

1.0–1.05

<0.02

 APACHE III score

1.04

1.01–1.05

<0.001

 Sepsis, yes/no

1.3

0.6–2.7

0.53

 PaO2/FiO2

1.00

0.99–1.01

0.71

 Fluid strategy, liberal vs. conservative

1.3

0.6–2.6

0.44

  1. APACHE Acute Physiology and Chronic Health Evaluation, EPCR endothelial protein C receptor, FiO 2 fraction of inspired oxygen, PaO 2 partial pressure of arterial oxygen, SNP single-nucleotide polymorphism, THBD thrombomodulin gene, TM thrombomodulin
  2. Models are adjusted for age, APACHE III score, presence of sepsis, baseline PaO2/FiO2 ratio, and allocation to fluid management arm