Skip to main content

Table 7 Performances of BDG (cutoff 80, 100 and 200 pg/mL), CAGTA, MANNAN biomarkers and C-PCR used combined for IC diagnosis

From: Contribution of Candida biomarkers and DNA detection for the diagnosis of invasive candidiasis in ICU patients with severe abdominal conditions

Invasive candidiasis   Sensitivity % Specificity % NPV % PPV %
(95 % CI) (95 % CI) (95 % CI) (95 % CI)
BDG ≥80 pg/mL CAGTA 90.3 (74.2–98.0) 42.1 (35.2–49.2) 96.6 (90.5–98.8) 19.3 (16.9–22.0)
  Mannan-Ag 80.6 (62.5–92.5) 44.1 (37.1–51.2) 93.7 (87.7–96.9) 18.1 (15.2–21.5)
Mannan-Ab 74.2 (42.9–57.1) 50.0 (42.9–57.1) 92.7 (87.2–95.9) 18.5 (15.1–22.6)
C-PCR 76.0 (54.9–90.6) 40.0 (29.5–51.2) 85.0 (72.9–92.3) 27.1 (22.0–33.0)
BDG ≥100 pg/mL CAGTA 83.9 (66.3–94.5) 44.1 (37.1–51.2) 94.7 (88.7–97.6) 18.7 (15.9–21.9)
  Mannan-Ag 74.2 (55.4–88.1) 46.5 (39.5–53.7) 92.2 (86.4–95.6) 17.6 (14.3–21.4)
Mannan-Ab 67.7 (48.6–83.3) 53.5 (46.3–60.5) 91.5 (86.5–94.8) 18.3 (14.4–22.9)
C-PCR 72.0 (50.6–87.9) 44.7 (33.9–55.9) 84.4 (73.5–91.4) 27.7 (21.9–34.3)
BDG ≥200 pg/mL CAGTA 77.4 (58.9–96.9) 55.9 (48.8–62.9) 94.2 (89.3–96.9) 21.2 (17.4–25.6)
  Mannan-Ag 71.0 (52.0–85.8) 57.9 (50.8–64.8) 92.9 (88.1–95.8) 20.6 (16.4–25.5)
Mannan-Ab 64.5 (45.4–80.8) 70.8 (64.0–77.0) 92.9 (88.9–95.5) 25.3 (19.5–32.2)
C-PCR 72.0 (50.6–87.9) 60.0 (48.8–70.5) 87.9 (79.1–93.3) 34.6 (27.0–43.1)
CAGTA positive Mannan-Ag 67.7 (48.6–83.3) 51.0 (43.9–58.1) 91.2 (85.9–94.6) 17.5 (13.8–21.9)
  Mannan-Ab 64.5 (45.4–80.8) 57.9 (50.8–64.8) 91.4 (86.7–94.5) 19.0 (14.8–24.2)
C-PCR 56.0 (34.9–75.6) 55.3 (44.1–66.1) 81.0 (72.5–87.4) 26.9 (19.5–35.9)
C-PCR positive Mannan-Ag 60.0 (38.7–78.9) 63.5 (52.4–73.7) 84.4 (76.5–90.0) 32.6 (24.0–42.5)
  Mannan-Ab 54.8 (36.0–72.7) 78.7 (72.4–84.1) 91.9 (88.4–94.4) 28.3 (20.7–37.5)
Mannan-Ag positive Mannan-Ab 54.8 (36.0–72.7) 59.9 (52.8–66.7) 89.6 (85.2–92.8) 17.3 (12.8–23.1)
  1. Combined biomarkers and C-PCR: two consecutive determinations positive or/and at least one of the biomarkers (in one determination) positive. C-PCR: one determination positive
  2. BDG (1-3)-ß-D-glucan, CAGTA Candida albicans germ tube antibody, mannan-Ag mannan antigen, mannan-Ab mannan antibody, C-PCR PCR-based Candida detection