|
Invasive candidiasis
| |
Sensitivity %
|
Specificity %
|
NPV %
|
PPV %
|
|---|
|
(95 % CI)
|
(95 % CI)
|
(95 % CI)
|
(95 % CI)
|
|---|
|
BDG ≥80 pg/mL
|
CAGTA
|
90.3 (74.2–98.0)
|
42.1 (35.2–49.2)
|
96.6 (90.5–98.8)
|
19.3 (16.9–22.0)
|
| |
Mannan-Ag
|
80.6 (62.5–92.5)
|
44.1 (37.1–51.2)
|
93.7 (87.7–96.9)
|
18.1 (15.2–21.5)
|
|
Mannan-Ab
|
74.2 (42.9–57.1)
|
50.0 (42.9–57.1)
|
92.7 (87.2–95.9)
|
18.5 (15.1–22.6)
|
|
C-PCR
|
76.0 (54.9–90.6)
|
40.0 (29.5–51.2)
|
85.0 (72.9–92.3)
|
27.1 (22.0–33.0)
|
|
BDG ≥100 pg/mL
|
CAGTA
|
83.9 (66.3–94.5)
|
44.1 (37.1–51.2)
|
94.7 (88.7–97.6)
|
18.7 (15.9–21.9)
|
| |
Mannan-Ag
|
74.2 (55.4–88.1)
|
46.5 (39.5–53.7)
|
92.2 (86.4–95.6)
|
17.6 (14.3–21.4)
|
|
Mannan-Ab
|
67.7 (48.6–83.3)
|
53.5 (46.3–60.5)
|
91.5 (86.5–94.8)
|
18.3 (14.4–22.9)
|
|
C-PCR
|
72.0 (50.6–87.9)
|
44.7 (33.9–55.9)
|
84.4 (73.5–91.4)
|
27.7 (21.9–34.3)
|
|
BDG ≥200 pg/mL
|
CAGTA
|
77.4 (58.9–96.9)
|
55.9 (48.8–62.9)
|
94.2 (89.3–96.9)
|
21.2 (17.4–25.6)
|
| |
Mannan-Ag
|
71.0 (52.0–85.8)
|
57.9 (50.8–64.8)
|
92.9 (88.1–95.8)
|
20.6 (16.4–25.5)
|
|
Mannan-Ab
|
64.5 (45.4–80.8)
|
70.8 (64.0–77.0)
|
92.9 (88.9–95.5)
|
25.3 (19.5–32.2)
|
|
C-PCR
|
72.0 (50.6–87.9)
|
60.0 (48.8–70.5)
|
87.9 (79.1–93.3)
|
34.6 (27.0–43.1)
|
|
CAGTA positive
|
Mannan-Ag
|
67.7 (48.6–83.3)
|
51.0 (43.9–58.1)
|
91.2 (85.9–94.6)
|
17.5 (13.8–21.9)
|
| |
Mannan-Ab
|
64.5 (45.4–80.8)
|
57.9 (50.8–64.8)
|
91.4 (86.7–94.5)
|
19.0 (14.8–24.2)
|
|
C-PCR
|
56.0 (34.9–75.6)
|
55.3 (44.1–66.1)
|
81.0 (72.5–87.4)
|
26.9 (19.5–35.9)
|
|
C-PCR positive
|
Mannan-Ag
|
60.0 (38.7–78.9)
|
63.5 (52.4–73.7)
|
84.4 (76.5–90.0)
|
32.6 (24.0–42.5)
|
| |
Mannan-Ab
|
54.8 (36.0–72.7)
|
78.7 (72.4–84.1)
|
91.9 (88.4–94.4)
|
28.3 (20.7–37.5)
|
|
Mannan-Ag positive
|
Mannan-Ab
|
54.8 (36.0–72.7)
|
59.9 (52.8–66.7)
|
89.6 (85.2–92.8)
|
17.3 (12.8–23.1)
|
- Combined biomarkers and C-PCR: two consecutive determinations positive or/and at least one of the biomarkers (in one determination) positive. C-PCR: one determination positive
-
BDG (1-3)-ß-D-glucan, CAGTA Candida albicans germ tube antibody, mannan-Ag mannan antigen, mannan-Ab mannan antibody, C-PCR PCR-based Candida detection
