| |
Candida spp. colonization
| |
|---|
|
NCI
|
LGCC
|
HGCC
|
IAC
|
Candidemia
|
P
|
|---|
|
N = 48
|
N = 130
|
N = 24
|
N = 20
|
N = 11
| |
|---|
|
BDG ≥80 pg/mL
|
CAGTA
|
21 (43.8)a
|
75 (57.7)a
|
21 (87.5)b
|
18 (90.0)b
|
10 (90.9)b
|
< .001
|
| |
Mannan-Ag
|
21 (43.8)a
|
71 (54.6)a,c
|
21 (87.5)b
|
16 (80.0)b
|
9 (81.8)b,c
|
<.001
|
|
Mannan-Ab
|
21 (43.8)a
|
61 (46.9)a
|
19 (79.2)b,c
|
15 (75.0)c
|
8 (72.7)a,c
|
.002
|
|
C-PCR
|
14/23 (60.9)
|
32/54 (59.3)
|
5/8 (62.5)
|
11/14 (78.6)
|
8/11 (72.7)
|
.724
|
|
BDG ≥100 pg/mL
|
CAGTA
|
21 (43.8)a
|
72 (55.4)a
|
20 (83.3)b
|
16 (80.0)b
|
10 (90.9)b
|
< .001
|
| |
Mannan-Ag
|
21 (43.8)a
|
68 (52.3)a, c
|
19 (79.2)b
|
14 (70.0)a, b, c
|
9 (81.8)c
|
.009
|
|
Mannan-Ab
|
21 (43.8)
|
57 (43.8)
|
16 (66.7)
|
13 (65.0)
|
8 (72.7)
|
.053
|
|
C-PCR
|
14/23 (60.9)
|
28/54 (51.9)
|
5/8 (62.5)
|
10/14 (71.4)
|
8/11 (72.7)
|
.606
|
|
BDG ≥200 pg/mL
|
CAGTA
|
16 (33.3)a
|
54 (41.5)a
|
19 (79.2)b
|
14 (70.0)b
|
10 (90.9)b
|
< .001
|
| |
Mannan-Ag
|
15 (31.2)a
|
52 (40.0)a
|
18 (75.0)b
|
13 (65.0)b
|
9 (81.8)b
|
< .001
|
|
Mannan-Ab
|
13 (27.1)a
|
33 (25.4)a
|
13 (54.2)b
|
12 (60.0)b
|
8 (72.7)b
|
< .001
|
|
C-PCR
|
10/23 (43.5)
|
21/54 (38.9)
|
3/8 (37.5)
|
10/14 (71.4)
|
8/11 (72.7)
|
.089
|
|
CAGTA positive
|
Mannan-Ag
|
15 (31.2)a
|
63 (48.5)b
|
21 (87.5)c
|
11 (55.0)a,b
|
10 (90.9)c
|
< .001
|
| |
Mannan-Ab
|
14 (29.2)a
|
53 (40.8)a,c
|
18 (75.0)b
|
12 (60.0)b,c
|
8 (72.7)b
|
< .001
|
|
C-PCR
|
8/23 (34.8)
|
25/54 (46.3)
|
5/8 (62.5)
|
6/14 (42.9)
|
8/11 (72.7)
|
.278
|
|
C-PCR positive
|
Mannan-Ag
|
5/23 (21.7)a
|
21/54 (38.9)a
|
5/8 (62.5)a,b
|
7/14 (50.0)a
|
8/11 (72.7)b
|
.037
|
| |
Mannan-Ab
|
8/23 (34.8)
|
19/54 (35.2)
|
1/8 (12.5)
|
7/14 (50.0)
|
8/11 (72.7)
|
.073
|
|
Mannan-Ag positive
|
Mannan-Ab
|
13 (27.1)a
|
51 (39.2)a,b
|
17 (70.8)c
|
12 (60.0)b,c
|
5 (45.5)a,c
|
.003
|
- Values are frequencies and percentages. Combined biomarkers and C-PCR: two consecutive determinations positives or/and at least one of each biomarkers (in one determination) positive. C-PCR: one determination positive
-
NCI neither colonized nor infected, LGCC low-grade Candida spp. colonization, HGCC high-grade Candida spp. colonization, IAC intra-abdominal candidiasis, BDG (1-3)-ß-D-glucan, CAGTA Candida albicans germ tube antibody, mannan-Ag mannan antigen, mannan-Ab mannan antibody, C-PCR PCR-based Candida detection
- Different superscripts (a,b,c) indicate nominally significant differences (P < .05)
