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Table 6 Number of patients with BDG (cutoff 80, 100 and 200 pg/mL) CAGTA, MANNAN biomarkers and Candida PCR positives used combined in the five study groups

From: Contribution of Candida biomarkers and DNA detection for the diagnosis of invasive candidiasis in ICU patients with severe abdominal conditions

  Candida spp. colonization  
NCI LGCC HGCC IAC Candidemia P
N = 48 N = 130 N = 24 N = 20 N = 11  
BDG ≥80 pg/mL CAGTA 21 (43.8)a 75 (57.7)a 21 (87.5)b 18 (90.0)b 10 (90.9)b < .001
  Mannan-Ag 21 (43.8)a 71 (54.6)a,c 21 (87.5)b 16 (80.0)b 9 (81.8)b,c <.001
Mannan-Ab 21 (43.8)a 61 (46.9)a 19 (79.2)b,c 15 (75.0)c 8 (72.7)a,c .002
C-PCR 14/23 (60.9) 32/54 (59.3) 5/8 (62.5) 11/14 (78.6) 8/11 (72.7) .724
BDG ≥100 pg/mL CAGTA 21 (43.8)a 72 (55.4)a 20 (83.3)b 16 (80.0)b 10 (90.9)b < .001
  Mannan-Ag 21 (43.8)a 68 (52.3)a, c 19 (79.2)b 14 (70.0)a, b, c 9 (81.8)c .009
Mannan-Ab 21 (43.8) 57 (43.8) 16 (66.7) 13 (65.0) 8 (72.7) .053
C-PCR 14/23 (60.9) 28/54 (51.9) 5/8 (62.5) 10/14 (71.4) 8/11 (72.7) .606
BDG ≥200 pg/mL CAGTA 16 (33.3)a 54 (41.5)a 19 (79.2)b 14 (70.0)b 10 (90.9)b < .001
  Mannan-Ag 15 (31.2)a 52 (40.0)a 18 (75.0)b 13 (65.0)b 9 (81.8)b < .001
Mannan-Ab 13 (27.1)a 33 (25.4)a 13 (54.2)b 12 (60.0)b 8 (72.7)b < .001
C-PCR 10/23 (43.5) 21/54 (38.9) 3/8 (37.5) 10/14 (71.4) 8/11 (72.7) .089
CAGTA positive Mannan-Ag 15 (31.2)a 63 (48.5)b 21 (87.5)c 11 (55.0)a,b 10 (90.9)c < .001
  Mannan-Ab 14 (29.2)a 53 (40.8)a,c 18 (75.0)b 12 (60.0)b,c 8 (72.7)b < .001
C-PCR 8/23 (34.8) 25/54 (46.3) 5/8 (62.5) 6/14 (42.9) 8/11 (72.7) .278
C-PCR positive Mannan-Ag 5/23 (21.7)a 21/54 (38.9)a 5/8 (62.5)a,b 7/14 (50.0)a 8/11 (72.7)b .037
  Mannan-Ab 8/23 (34.8) 19/54 (35.2) 1/8 (12.5) 7/14 (50.0) 8/11 (72.7) .073
Mannan-Ag positive Mannan-Ab 13 (27.1)a 51 (39.2)a,b 17 (70.8)c 12 (60.0)b,c 5 (45.5)a,c .003
  1. Values are frequencies and percentages. Combined biomarkers and C-PCR: two consecutive determinations positives or/and at least one of each biomarkers (in one determination) positive. C-PCR: one determination positive
  2. NCI neither colonized nor infected, LGCC low-grade Candida spp. colonization, HGCC high-grade Candida spp. colonization, IAC intra-abdominal candidiasis, BDG (1-3)-ß-D-glucan, CAGTA Candida albicans germ tube antibody, mannan-Ag mannan antigen, mannan-Ab mannan antibody, C-PCR PCR-based Candida detection
  3. Different superscripts (a,b,c) indicate nominally significant differences (P < .05)