|
Invasive candidiasis
|
Sensitivity %
|
Specificity %
|
NPV %
|
PPV %
|
|---|
|
(95 % CI)
|
(95 % CI)
|
(95 % CI)
|
(95 % CI)
|
|---|
|
BDG ≥ 80 pg/mL
|
76.7 (57.7–90.1)
|
57.2 (49.9–64.3)
|
94.1 (89.1–96.8)
|
21.7 (17.7–26.4)
|
|
BDG ≥ 100 pg/mL
|
70.0 (50.6–85.3)
|
61.5 (54.3–68.4)
|
93.0 (88.4–95.9)
|
21.9 (17.3–27.3)
|
|
BDG ≥ 200 pg/mL
|
60.0 (40.6–77.3)
|
79.4 (73.1–84.8)
|
92.9 (89.4–95.4)
|
30.5 (22.7–39.6)
|
|
CAGTA positive
|
53.3 (34.3–71.7)
|
64.3 (57.2–71.0)
|
90.1 (86.0–93.2)
|
18.4 (13.3–24.8)
|
|
Mannan-Ag positive
|
43.3 (25.5–62.6)
|
67.3 (60.3–73.8)
|
88.7 (85.0–91.6)
|
16.7 (11.3–24.0)
|
|
Mannan-Ab positive
|
25.8 (11.9–44.6)
|
89.0 (83.8–93.0)
|
88.6 (86.2–90.6)
|
26.7 (15.1– 42.6)
|
|
C-PCR positive
|
84.0 (63.9–95.5)
|
32.9 (23.1–44.0)
|
87.5 (73.1–94.8)
|
26.9 (22.7–31.6)
|
- Values are frequencies and percentages. Biomarker positives: two determinations consecutives positives (≥ cutoff). C-PCR positive: one determination positive
-
NCI neither colonized nor infected, LGCC low-grade Candida spp. colonization, HGCC high-grade Candida spp. colonization, IAC intra-abdominal candidiasis, BDG (1-3)-ß-D-glucan, CAGTA Candida albicans germ tube antibody, mannan-Ag mannan antigen; mannan-Ab mannan antibody, C-PCR PCR-based Candida detection
