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Table 5 Performances of BDG (cutoff 80, 100 and 200 pg/mL), CAGTA, MANNAN biomarkers and C-PCR used alone for IC diagnosis

From: Contribution of Candida biomarkers and DNA detection for the diagnosis of invasive candidiasis in ICU patients with severe abdominal conditions

Invasive candidiasis Sensitivity % Specificity % NPV % PPV %
(95 % CI) (95 % CI) (95 % CI) (95 % CI)
BDG ≥ 80 pg/mL 76.7 (57.7–90.1) 57.2 (49.9–64.3) 94.1 (89.1–96.8) 21.7 (17.7–26.4)
BDG ≥ 100 pg/mL 70.0 (50.6–85.3) 61.5 (54.3–68.4) 93.0 (88.4–95.9) 21.9 (17.3–27.3)
BDG ≥ 200 pg/mL 60.0 (40.6–77.3) 79.4 (73.1–84.8) 92.9 (89.4–95.4) 30.5 (22.7–39.6)
CAGTA positive 53.3 (34.3–71.7) 64.3 (57.2–71.0) 90.1 (86.0–93.2) 18.4 (13.3–24.8)
Mannan-Ag positive 43.3 (25.5–62.6) 67.3 (60.3–73.8) 88.7 (85.0–91.6) 16.7 (11.3–24.0)
Mannan-Ab positive 25.8 (11.9–44.6) 89.0 (83.8–93.0) 88.6 (86.2–90.6) 26.7 (15.1– 42.6)
C-PCR positive 84.0 (63.9–95.5) 32.9 (23.1–44.0) 87.5 (73.1–94.8) 26.9 (22.7–31.6)
  1. Values are frequencies and percentages. Biomarker positives: two determinations consecutives positives (≥ cutoff). C-PCR positive: one determination positive
  2. NCI neither colonized nor infected, LGCC low-grade Candida spp. colonization, HGCC high-grade Candida spp. colonization, IAC intra-abdominal candidiasis, BDG (1-3)-ß-D-glucan, CAGTA Candida albicans germ tube antibody, mannan-Ag mannan antigen; mannan-Ab mannan antibody, C-PCR PCR-based Candida detection