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Table 4 Number of patients with BDG (cutoff 80, 100 and 200 pg/mL), CAGTA, MANNAN biomarkers and Candida PCR positives used alone in the five study groups

From: Contribution of Candida biomarkers and DNA detection for the diagnosis of invasive candidiasis in ICU patients with severe abdominal conditions

  Candida spp colonization
NCI LGCC HGCC IAC Candidemia P
N = 48 N = 130 N = 24 N = 20 N = 11  
BDG ≥ 80 pg/mL, no. (%) 16/46 (34.8)a 50/124 (40.3)a 17/24 (70.8)b 15/20 (75.0)b 8/10 (80.0)b < .001
BDG ≥ 100 pg/mL, no. (%) 16/46 (34.8)a 45/125 (36.0)a 14/24 (58.3)a,b 13/20 (65.0)b 8/10 (80.0) b .004
BDG ≥ 200 pg/mL, no. (%) 10/47 (21.3)a 20/128 (15.6)a 11/24 (45.8)b 10/20 (50.0)b 8/10 (80.0)b < .001
CAGTA positive, no. (%) 10/47 (21.3)a 44/128 (34.4)a 17/24 (70.8)b 8/20 (40.0)a,b 8/10 (80.0)b < .001
Mannan-Ag positive, no. (%) 10/48 (20.8)a 40/127 (31.5)a 15/24 (62.5)b 8/20 (40.0)a,b 5/10 (50.0)a,b .007
Mannan-Ab positive, no. (%) 6/48 (12.5) 12/128 (9.4) 4/24 (16.7) 5/20 (25.0) 3/11 (27.3) .126
C-PCR positive, no. (%) 14/23 (60.9) 37/54 (68.5) 6/8 (75.0) 12/14 (85.7) 9/11(81.8) .525
  1. Values are frequencies and percentages. Different superscripts (a,b) indicate nominally significant differences (P < 0.05). Biomarker positives: two determinations consecutives positives (≥ cutoff). C-PCR positive: one determination positive
  2. NCI neither colonized nor infected, LGCC low-grade Candida spp. colonization, HGCC high-grade Candida spp. colonization, IAC intra-abdominal candidiasis, BDG (1-3)-ß-D-glucan, CAGTA Candida albicans germ tube antibody, mannan-Ag mannan antigen, mannan-Ab mannan antibody, C-PCR PCR-based Candida detection