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Table 2 Characteristics of the study population according to colonization and infection status

From: Contribution of Candida biomarkers and DNA detection for the diagnosis of invasive candidiasis in ICU patients with severe abdominal conditions

 

Diagnosis

P value

Total

NCI

LGCC

HGCC

IAC

Candidemia

(n = 233)

(n = 48)

(n = 130)

(n = 24)

(n = 20)

(n = 11)

 

Age, years, mean (± SD)

66.7 ± 13.2

66.9 ± 11.9

65.8 ± 13.9

70.7 ± 9.2

67.1 ± 15.7

67.5 ± 12.2

.597

Male/female, %

67.0/33.0

72.9/27.1

70.0/30.0

50.0/50.0

60.0/40.0

54.5/45.5

.228

ICU admission

       

 APACHE II

18.4 ± 6.3

18.1 ± 6.2

18.5 ± 6.1

18.2 ± 7.1

19.6 ± 7.0

18.3 ± 6.5

.925

 SOFAa

7 (5 ; 9)

6.5 (5 ; 8)

7 (5 ; 10)

7.5 (4.5; 9.5)

6.5 (4 ; 10)

7.5 (5 ; 9)

.583

Maximum score during ICU stay

       

 APACHE II

18.7 ± 6.3

17.7 ± 6.6

18.3 ± 6.1

21.4 ± 7.7

19.4 ± 5.0

19.5 ± 4.7

.162

 SOFAa

7 (5–10)

7 (4–9)

7 (5–10)

7 (5–10)

7 (5–12)

9 (5.5–10)

.702

Candida scorea

4 (3–4)

3 (2–4)

4 (3–4)

4 (3–5)

4.5 (4–5)

3 (3–4)

< .001

ICU length of stay, daysa

15 (10–25)

12 (8–19)

14 (9–25)

21 (17–28)

14 (11–19)

16 (8–38)

.017

Hospital length of stay, daysa

37 (21–57)

34 (22–45)

33 (19–59)

48 (33–68)

37 (26–58)

40 (32–59)

.097

Patient type, no. (%)

      

.180

 Medical

22 (9.4)

5 (10.4)

12 (9.2)

2 (8.3)

0

3 (27.3)

 

 Surgical*

211 (90.6)

43 (89.6)

118 (90.8)

22 (91.7)

20 (100)

8 (72.7)

 

Pancreatitis not intervened

22 (9.4)

5 (10.4)

12 (9.2)

2 (8.3)

0

3 (27.3)

.232

Site of abdominal surgery, no. (%)

      

.701

Esophagus

13 (6.2)

4 (9.3)

5 (4.2)

2 (9.1)

2 (10.0)

0

 

Stomach/duodenum

21 (10.0)

1 (2.3)

14 (11.9)

3 (13.6)

3 (15.0)

0

 

Biliary tract/pancreas

58 (27.5)

9 (20.9)

38 (32.2)

5 (22.7)

3 (15.0)

3 (37.5)

 

Small intestine

45 (21.3)

13 (30.2)

21 (17.8)

4 (18.2)

5 (25.0)

2 (25.0)

 

Colon

59 (28.0)

12 (27.9)

32 (27.1)

6 (27.3)

6 (30.0)

3 (37.5)

 

Others

15 (7.1)

4 (9.3)

8 (6.8)

2 (9.1)

1 (5.0)

0

 

Surgery type**, no. (%)

      

.556

 Emergency

135 (64.0)

24 (55.8)

78 (66.1)

13 (59.1)

15 (75.0)

5 (62.2)

 

 Elective

76 (36.0)

19 (44.2)

40 (33.9)

9 (40.9)

5 (25.0)

3 (37.5)

 

Surgical procedure**, no. (%)

      

.023

 One

113 (53.6)

23 (53.5)

70 (59.3)

11 (50.0)

4 (20.0)

5 (62.5)

 

  ≥ Two

98 (46.4)

20 (46.5)

48 (40.7)

11 (50.0)

16 (80.0)

3 (37.5)

 

Underlying illnesses, no. (%)

       

 Solid tumor

84 (36.1)

19 (39.6)

43 (33.1)

10 (41.7)

8 (40.0)

4 (36.4)

.853

 Diabetes mellitus

67 (28.8)

13 (27.1)

35 (26.9)

8 (33.3)

7 (35.0)

4 (36.4)

.830

 COPD

37 (15.9)

13 (27.1)

17 (13.1)

3 (12.5)

4 (20.0)

0

.112

 Chronic renal failure

26 (11.2)

3 (6.2)

14 (10.8)

5 (20.8)

2 (10.0)

2 (18.2)

.337

 Heart failure

16 (6.9)

3 (6.2)

6 (4.6)

5 (20.8)

0

2 (18.2)

.023

 Chronic liver failure

9 (3.9)

4 (8.3)

3 (2.3)

2 (8.3)

0

0

.201

 Oncohematologic process

3 (1.3)

0

2 (1.5)

1 (4.2)

0

0

.635

Antifungal treatment, no. (%)

119 (51.1)

21 (43.8)

58 (44.6)

11 (45.8)

18 (90.0)

11 (100)

< .001

ICU mortality, no. (%)

50 (21.5)

8 (16.7)

30 (23.1)

7 (29.7)

4 (20.0)

1 (9.1)

.605

Overall mortality, no. (%)

68 (29.2)

10 (20.8)

41 (31.5)

8 (33.3)

8 (40.0)

1 (9.1)

.277

  1. Values are expressed as frequencies and percentages; mean ± standard deviation (SD); amedian (25th-75th percentiles); P value: statistical significance
  2. NCI neither colonized nor infected, LGCC low-grade Candida spp. colonization, HGCC high-grade Candida spp. colonization, IAC intra-abdominal candidiasis, ICU intensive care unit, APACHE II Acute Physiology and Chronic Health Evaluation, SOFA Sequential Organ Failure Assessment, COPD chronic obstructive pulmonary disease
  3. *Abdominal surgery; **211 patients, first surgical procedure