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Fig. 3 | Critical Care

Fig. 3

From: Beyond muscle destruction: a systematic review of rhabdomyolysis for clinical practice

Fig. 3

Acute kidney injury in rhabdomyolysis. Enzymes*: creatine kinase, aldolase, lactate dehydrogenase. After muscle destruction, myoglobin and enzymes released into the circulation damage capillaries, leading to leakage and edema. Hypovolemia and the decrease in renal bood flow is associated with acute kidney injury. Myoglobin cytotoxicity affects the kidney by lipid peroxidation and production of reactive oxygen species. Tubular obstruction by myoglobin is also associated with AKI

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