TY - JOUR AU - Bouglé, Adrien AU - Rocheteau, Pierre AU - Sharshar, Tarek AU - Chrétien, Fabrice PY - 2016 DA - 2016/05/19 TI - Muscle regeneration after sepsis JO - Critical Care SP - 131 VL - 20 IS - 1 AB - Severe critical illness is often complicated by intensive care unit-acquired weakness (ICU-AW), which is associated with increased ICU and post-ICU mortality, delayed weaning from mechanical ventilation and long-term functional disability. Several mechanisms have been implicated in the pathophysiology of ICU-AW, but muscle regeneration has not been investigated to any extent in this context, even though its involvement is suggested by the protracted functional consequences of ICU-AW. Recent data suggest that muscle regeneration could be impaired after sepsis, and that mesenchymal stem cell treatment could improve the post-injury muscle recovery. SN - 1364-8535 UR - https://doi.org/10.1186/s13054-016-1308-3 DO - 10.1186/s13054-016-1308-3 ID - Bouglé2016 ER -