Fig. 3From: Efficacy and safety of proton pump inhibitors for stress ulcer prophylaxis in critically ill patients: a systematic review and meta-analysis of randomized trialsOvert upper gastrointestinal bleeding. Data from 17 trials (n = 1897 patients) are included, analyzed using the random effects model. Proton pump inhibitors (PPIs) were associated with a significantly lower risk of overt bleeding compared to histamine-2-receptor antagonists (H2RAs). IV Inverse VarianceBack to article page