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Table 2 Baseline characteristics of the patients with septic shock

From: Monocyte programmed death ligand-1 expression after 3–4 days of sepsis is associated with risk stratification and mortality in septic patients: a prospective cohort study

Parameters

Survivors

Nonsurvivors

Overall population

P value

Number

49

27

76

Age (years)

73 (62–78)

70 (61–78)

71 (61–78)

0.765

Male, n (%)

22 (44.9 %)

15 (55.6 %)

37 (48.7 %)

0.792

WBC (×109/L)

14.9 (12.4–16.9)

13.3 (10.9–17.8)

14.9 (11.8–17.2)

0.641

Lymphocyte (×109/L)

0.78 (0.59–1.24)

0.65 (0.52–0.82)

0.76 (0.54–1.07)

0.046

SOFA score

11 (9–12)

14 (12–17)

11 (9–14)

<0.001

SAPS II

50 (43–56)

60 (53–66)

53 (46–60)

<0.001

Percentage of PD-1+/CD4+ T cells (%)

35.1 (28.5–44.8)

42.9 (34.9–49.0)

38.2 (29.2–47.7)

0.034

MFI of PD-1 on CD4+ T cells

7.0 (5.7–8.9)

8.8 (7.1–9.6)

7.5 (6.0–9.4)

0.036

Percentage of PD-1+/CD8+ T cells (%)

33.0 (24.8–44.3)

47.1 (30.3–53.9)

36.5 (27.3–51.3)

0.032

MFI of PD-1 on CD8+ T cells

5.9 (4.7–8.1)

7.8 (5.4–9.8)

6.6 (4.9–8.4)

0.033

Percentage of PD-L1+/CD4+ T cells (%)

16.4 (8.6–28.4)

22.1 (12.0–34.0)

21.0 (9.3–30.6)

0.295

MFI of PD-L1 on CD4+ T cells

1.9 (1.5–2.0)

1.8 (1.6–2.2)

1.8 (1.5–2.0)

0.961

Percentage of PD-L1+/CD8+ T cells (%)

23.2 (10.8–38.9)

12.9 (9.9–32.5)

19.5 (10.3–37.4)

0.204

MFI of PD-L1 on CD8+ T cells

1.6 (1.4–1.9)

1.5 (1.4–1.7)

1.5 (1.4–1.8)

0.378

Percentage of monocytes expressing PD-L1 (%)

28.9 (17.9–43.6)

53.9 (31.8–72.9)

35.9 (20.4–54.7)

0.001

MFI of PD-L1 on monocytes

8.2 (7.5–9.0)

9.1 (8.1–11.3)

8.3 (7.7–9.7)

0.012

Type of infection, n (%)

   

Pneumonia

27 (55.1 %)

14 (51.9 %)

41 (53.9 %)

0.786

IAI

8 (16.3 %)

3 (11.1 %)

11 (14.5 %)

0.781

CNSI

4 (8.2 %)

2 (7.4 %)

6 (7.9 %)

0.743

USI

10 (20.4 %)

8 (29.6 %)

18 (23.7 %)

0.366

Number of comorbidities

   

≥1, n (%)

21 (42.9 %)

18 (66.7 %)

39 (51.3 %)

0.047

  1. Data are shown as median and interquartile range unless otherwise indicated
  2. CNSI central nervous system infection, IAI intra-abdominal infection, MFI mean of fluorescence intensities, PD-1 Programmed cell death receptor-1, PD-L1 programmed cell death receptor ligand-1, SAPS II simplified acute physiology score II, SOFA sepsis-related organ failure assessment, USI urinary system infection, WBC white blood cells