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Table 2 Baseline characteristics of the patients with septic shock

From: Monocyte programmed death ligand-1 expression after 3–4 days of sepsis is associated with risk stratification and mortality in septic patients: a prospective cohort study

Parameters Survivors Nonsurvivors Overall population P value
Number 49 27 76
Age (years) 73 (62–78) 70 (61–78) 71 (61–78) 0.765
Male, n (%) 22 (44.9 %) 15 (55.6 %) 37 (48.7 %) 0.792
WBC (×109/L) 14.9 (12.4–16.9) 13.3 (10.9–17.8) 14.9 (11.8–17.2) 0.641
Lymphocyte (×109/L) 0.78 (0.59–1.24) 0.65 (0.52–0.82) 0.76 (0.54–1.07) 0.046
SOFA score 11 (9–12) 14 (12–17) 11 (9–14) <0.001
SAPS II 50 (43–56) 60 (53–66) 53 (46–60) <0.001
Percentage of PD-1+/CD4+ T cells (%) 35.1 (28.5–44.8) 42.9 (34.9–49.0) 38.2 (29.2–47.7) 0.034
MFI of PD-1 on CD4+ T cells 7.0 (5.7–8.9) 8.8 (7.1–9.6) 7.5 (6.0–9.4) 0.036
Percentage of PD-1+/CD8+ T cells (%) 33.0 (24.8–44.3) 47.1 (30.3–53.9) 36.5 (27.3–51.3) 0.032
MFI of PD-1 on CD8+ T cells 5.9 (4.7–8.1) 7.8 (5.4–9.8) 6.6 (4.9–8.4) 0.033
Percentage of PD-L1+/CD4+ T cells (%) 16.4 (8.6–28.4) 22.1 (12.0–34.0) 21.0 (9.3–30.6) 0.295
MFI of PD-L1 on CD4+ T cells 1.9 (1.5–2.0) 1.8 (1.6–2.2) 1.8 (1.5–2.0) 0.961
Percentage of PD-L1+/CD8+ T cells (%) 23.2 (10.8–38.9) 12.9 (9.9–32.5) 19.5 (10.3–37.4) 0.204
MFI of PD-L1 on CD8+ T cells 1.6 (1.4–1.9) 1.5 (1.4–1.7) 1.5 (1.4–1.8) 0.378
Percentage of monocytes expressing PD-L1 (%) 28.9 (17.9–43.6) 53.9 (31.8–72.9) 35.9 (20.4–54.7) 0.001
MFI of PD-L1 on monocytes 8.2 (7.5–9.0) 9.1 (8.1–11.3) 8.3 (7.7–9.7) 0.012
Type of infection, n (%)    
Pneumonia 27 (55.1 %) 14 (51.9 %) 41 (53.9 %) 0.786
IAI 8 (16.3 %) 3 (11.1 %) 11 (14.5 %) 0.781
CNSI 4 (8.2 %) 2 (7.4 %) 6 (7.9 %) 0.743
USI 10 (20.4 %) 8 (29.6 %) 18 (23.7 %) 0.366
Number of comorbidities    
≥1, n (%) 21 (42.9 %) 18 (66.7 %) 39 (51.3 %) 0.047
  1. Data are shown as median and interquartile range unless otherwise indicated
  2. CNSI central nervous system infection, IAI intra-abdominal infection, MFI mean of fluorescence intensities, PD-1 Programmed cell death receptor-1, PD-L1 programmed cell death receptor ligand-1, SAPS II simplified acute physiology score II, SOFA sepsis-related organ failure assessment, USI urinary system infection, WBC white blood cells