TY - JOUR AU - Shao, Rui AU - Fang, Yingying AU - Yu, Han AU - Zhao, Lianxing AU - Jiang, Zhifeng AU - Li, Chun-Sheng PY - 2016 DA - 2016/05/09 TI - Monocyte programmed death ligand-1 expression after 3–4 days of sepsis is associated with risk stratification and mortality in septic patients: a prospective cohort study JO - Critical Care SP - 124 VL - 20 IS - 1 AB - Septic shock is a major healthcare problem with a high mortality rate that might be caused by immunosuppression. Programmed cell death receptor-1 (PD-1) and programmed cell death receptor ligand-1 (PD-L1), which are co-inhibitory receptor molecules, participate in sepsis-induced immunosuppression. In this study, we investigated which PD-1-related molecules can be used to evaluate the risk stratification and prognosis of septic patients. Furthermore, we explored the prognostic significance of a combination of ideal predictors and conventional clinical risk parameters in septic shock patients. SN - 1364-8535 UR - https://doi.org/10.1186/s13054-016-1301-x DO - 10.1186/s13054-016-1301-x ID - Shao2016 ER -