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Fig. 3 | Critical Care

Fig. 3

From: Regional citrate versus heparin anticoagulation for continuous renal replacement therapy in critically ill patients: a meta-analysis with trial sequential analysis of randomized controlled trials

Fig. 3

Effect of regional citrate versus heparin anticoagulation on mortality. a Mortality. b Fixed-effect model of trial sequential analysis for mortality. A diversity-adjusted information size of 1021 participants calculated on the basis of a mortality rate of 42.66 % in the heparin group, relative risk reduction 20 %, α = 5 % (two sided), β = 20 %, I 2 = 0 %. Complete blue line represents cumulative Z-curve, which crossed the futility boundary (complete red line) and reached the futility area. AU Australia, DE Germany, CA Canada, NL The Netherlands, CH Switzerland, M-H Mantel-Haenszel

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Critical Care

ISSN: 1364-8535