Study | Methods (score) | Mortality, N (%)a | Infections, N (%)b | LOS, days, mean ± SD (N) | Mechanical ventilation, days, mean ± SD (N) | Caloric intakec | |||||
---|---|---|---|---|---|---|---|---|---|---|---|
EN | PN | EN | PN | EN | PN | EN | PN | EN | PN | ||
1. Rapp et al. 1983 [37] | C.Random: not sure | 9/18 (50) | 3/20 (15) | NR |  | Hospital 49.4d | Hospital 52.6d | 10.3d | 10.4d | 685 P = 0.001 | 1750 |
ITT: no | |||||||||||
Blinding: no (4) | |||||||||||
2. Adams et al. 1986 [38] | C.Random: not sure | 1/23 (4) | 3/23 (13) | 15/23 (65) | 17/23 (74) | ICU 13 ± 11 (19) | ICU 10 ± 10 (17) | 12 ± 11 (17) | 10 ± 10 (13) | 2088 NSf | 2572 |
ITT: yes | Hospital 30 ± 21 (19) | Hospital 31 ± 29 (17) |  | ||||||||
Blinding: no (8) | |||||||||||
3. Young et al. 1987 [39] | C.Random: not sure | 10/28 (36) | 10/23 (43) | 5/28 (18) | 4/23 (17) | NR |  | NR | 1671 P = 0.02 | 2299 | |
ITT: no | |||||||||||
Blinding: no (6) | |||||||||||
4. Peterson et al. 1988 [40] | C.Random: not sure | NR |  | 2/21 (10) | 8/25 (32) | ICU 3.7 ± 0.8 (21) | ICU 4.6 ± 1.0 (25) | NR | Kcal on day 5 | ||
2204 P = 0.04 | 2548 | ||||||||||
ITT: no | Hospital 13.2 ± 1.6 (21) | Hospital 14.6 ± 1.9 (24) | |||||||||
Blinding: no (5) | |||||||||||
5. Cerra et al. 1988 [41] | C.Random: not sure | ICU 7/31 (22) | ICU 8/35 (23) | NR | Â | NR | Â | NR | Non-protein kcal | ||
1684 NSf | 2000 | ||||||||||
ITT: no | |||||||||||
Blinding: no (2) | |||||||||||
6. Moore et al. 1989 [42] | C.Random: yes | NR | Â | 5/29 (17) | 11/30 (37) | NR | Â | NR | Non-protein kcal on day 5 | ||
ITT: no | 1847 P = 0.01 | 2261 | |||||||||
Blinding: no (10) | |||||||||||
7. Kudsk et al. 1992 [43] | C.Random: not sure | ICU 1/51 (2) | ICU 1/45 (2) | 9/51 (16) | 18/45 (40) | Hospital 20.5 ± 19.9 (51) | Hospital 19.6 ± 18.8 (45) | 2.8 ± 4.9 (51) | 3.2 ± 6.7 (45) | Kcal/kg/d | |
ITT: no | 15.7 P < 0.05 | 19.1 | |||||||||
Blinding: single (10) | |||||||||||
8. Dunham et al. 1994 [44] | C.Random: not sure | 1/12 (7) | 1/15 (8) | NR | Â | NR | Â | NR | NSf | Â | |
ITT: no | |||||||||||
Blinding: no (8) | |||||||||||
9. Borzotta et al. 1994 [45] | C.Random: not sure | 5/28 (18) | 1/21 (5) | 51/28 (28) | 39/21 (21) | Hospitale 39 ± 23.1 | Hospitale 36.9 ± 14 | NR | 2097 NSf | 1961 | |
ITT: no | |||||||||||
Blinding: no (6) | |||||||||||
10. Hadfield et al. 1995 [46] | C.Random: not sure | ICU 2/13 (15) | ICU 6/11 (55) | NR | Â | NR | Â | NR | NSf | Â | |
ITT: no | |||||||||||
Blinding: no (7) | |||||||||||
11. Kalfarentzos et al. 1997 [47] | C.Random: not sure | ICU 1/18 (6) | ICU 2/20 (10) | 5/18 (28) | 0/20 (50) | ICU 11 (5–21)d | ICU 12 (5–24)d | 15 (6–16)d | 11 (7–31)d | Non-protein kcal/kg/d | |
ITT: no | Hospital 40 (25–83)d | Hospital 39 (22–73)d | 24.1 NSf | 24.5 | |||||||
Blinding: single (9) | |||||||||||
12. Woodcock et al. 2001 [27] | C.Random: yes | 9/17 (53) | 5/21 (24) | 6/16 (38) | 11/21 (52) | 33.2 ± 43 (16) | 27.3 ± 18.7 (18) | NR | % caloric target (30 kcal/kg/d) achieved | ||
ITT: yes | 54.1 P < 0.001 | 96.7 | |||||||||
Blinding: single (12) | |||||||||||
13. Casas et al. 2007 [48] | C.Random: no/unsure | Hospital 0/11 (0) | Hospital 2/11 (18) | 1/11 (9) | 3/11 (27) | Hospital 30.2 (average) | Hospital 30.7 (average) | NR | Kcal/kg/d | ||
ITT: Yes | 20.1 NSf | 20.8 | |||||||||
Blinding: no (8) | |||||||||||
14. Chen et al. 2011 [49] | C.Random: yes | 20-day 11/49 (22) | 20-day 10/49 (20) | 5/49 (10) | 18/49 (37) | ICU 9.09 ± 2.75 | ICU 9.60 ± 3.06 | 7.95 ± 2.11 | 8.23 ± 2.42 | NR | |
ITT: yes | |||||||||||
Blinding: no (7) | Hospital 23.32 ± 5.6 | Hospital 22.24 ± 3.27 | |||||||||
15. Justo Meirelles et al. 2011 [21] | C.Random: no | Not specified 1/12 (8.3) | Not specified 1/10 (10) | Total infectious complications 2/12 (16.7) | Total infectious complications 4/10 (40) | ICU 14 (5–26) | ICU 14 (6–24) | NR | Cumulative kcal over 5d | ||
ITT: no | Pneumonia 2/12 (16.7) | Pneumonia 2/10 (20) | 5985 P = 0.34 | 6586 | |||||||
Blinding: no (5) | Sepsis 0 | Sepsis 2/10 (20) | |||||||||
16. Wang et al. 2013 [22] | C.Random: no | Hospital 3/61 (5) | Hospital 7/60 (12) | Pancreatic sepsis 13/61 (21) | Pancreatic sepsis 24/60 (40) | NR | Â | NR | NR | ||
ITT: no | |||||||||||
Blinding: double (7) | MODS 15/61 (24.6) | MODS 22/60 (36.7) | |||||||||
17. Sun et al. 2013 [50] | C.Random: no | Hospital 2/30 (7) | Hospital 1/30 (3) | Pancreatic 3/30 (10) | Pancreatic 10/30 (33) | ICU 9 (5–14) | ICU 12 (8–21) | NR | NR | ||
ITT: no | MODS 5/30 (17) | MODS 13/30 (43) | |||||||||
Blinding: no (6) | SIRS 12/30 (40) | SIRS 22/30 (73) | |||||||||
18. Harvey et al. 2014 [16] | C.Random: yes | ICU 352/1197 (29.4) | ICU 317/1190 (26.6) | Total infectious complications 194/1197 (16.2)g | Total infectious complications 194/1191 (16.3)g | ICU 11.3 ± 12.5 (1197) | ICU 12 ± 13.5 (1190) | 8.2 ± 9.3 (1197) | 8.7 ± 11.5 (1189) | Cumulative kcal/kg/d over 5d | |
ITT: yes | Hospital 450/1186 (37.9) | Hospital 431/1185 (36.4) | Pneumonia 143/1197 (11.9) | Pneumonia 135/1191 (11.3) | Hospital 26.8 ± 33.2 (1186) | Hospital 27.5 ± 33.9 (1185) | 74 NSf | 89 | |||
30-day 409/1195 (34.2) | 30-day 393/1188 (33.1) | Bloodstream infections 21/1197 (1.8) | Bloodstream infections 27/1191 (2.9) | ||||||||
Blinding: no (8) | 90-day 464/1188 (39.1) | 90-day 442/1184 (37.3) | Surgical infections 12/1197 (1.0) | Surgical infections 10/1191 (0.8) |