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Table 1 Included randomized controlled trials of enteral versus parenteral nutrition in critically ill patients

From: Enteral versus parenteral nutrition in critically ill patients: an updated systematic review and meta-analysis of randomized controlled trials

Author Year Population Setting Total patientsa EN group PN group Reference
Rapp et al. 1983 Head-injured patients Single-center 38 18 20 [37]
Adams et al. 1986 Critically ill trauma Single-center 46 23 23 [38]
Young et al. 1987 Brain-injured patients Single-center 51 28 23 [39]
Peterson et al. 1988 Critically ill patients with abdominal trauma Single-center 59 29 30 [40]
Cerra et al. 1988 Critically ill patients Single-center 70 33 37 [41]
Moore et al. 1989 Abdominal trauma Single-center 75 39 36 [42]
Kudsk et al. 1992 Abdominal trauma Single-center 98 52 46 [43]
Dunham et al. 1994 Blunt trauma Single-center 28b 12 16 [44]
Borzotta et al. 1994 Closed head injury Single-center 59 36 23 [45]
Hadfield et al. 1995 Mixed ICU medical-surgical Single-center 24 13 11 [46]
Kalfarentzos et al. 1997 Severe acute pancreatitis Single-center 38 18 20 [47]
Woodcock et al. 2001 ICU patients requiring nutrition support Single-center 38 17 21 [27]
Casas et al. 2007 Severe acute pancreatitis Single-center 22 11 11 [48]
Chen et al. 2011 Medical ICU Single-center 98b 49 49 [49]
Justo Meirelles et al. 2011 Traumatic brain injury Single-center 22 12 10 [21]
Wang et al. 2013 Surgical ICU (severe acute pancreatitis) Single-center 121b 61 60 [22]
Sun et al. 2013 Surgical ICU (severe acute pancreatitis) Single-center 60 30 30 [50]
Harvey et al. 2014 Mixed medical-surgical Multi-center 2400 1200 1200 [16]
  1. EN enteral nutrition ICU intensive care unit PN parenteral nutrition
  2. aTotal number includes number of ICU patients randomized in the trial, even if analysis was not according to intention-to-treat principle
  3. bPatients randomized to a third intervention group (combined enteral and parenteral nutrition) of the concerned trial were excluded from this meta-analysis