Enteral versus parenteral nutrition in critically ill patients: an updated systematic review and meta-analysis of randomized controlled trials

Table 1 Included randomized controlled trials of enteral versus parenteral nutrition in critically ill patients

Author	Year	Population	Setting	Total patients^a	EN group	PN group	Reference
Rapp et al.	1983	Head-injured patients	Single-center	38	18	20	[37]
Adams et al.	1986	Critically ill trauma	Single-center	46	23	23	[38]
Young et al.	1987	Brain-injured patients	Single-center	51	28	23	[39]
Peterson et al.	1988	Critically ill patients with abdominal trauma	Single-center	59	29	30	[40]
Cerra et al.	1988	Critically ill patients	Single-center	70	33	37	[41]
Moore et al.	1989	Abdominal trauma	Single-center	75	39	36	[42]
Kudsk et al.	1992	Abdominal trauma	Single-center	98	52	46	[43]
Dunham et al.	1994	Blunt trauma	Single-center	28^b	12	16	[44]
Borzotta et al.	1994	Closed head injury	Single-center	59	36	23	[45]
Hadfield et al.	1995	Mixed ICU medical-surgical	Single-center	24	13	11	[46]
Kalfarentzos et al.	1997	Severe acute pancreatitis	Single-center	38	18	20	[47]
Woodcock et al.	2001	ICU patients requiring nutrition support	Single-center	38	17	21	[27]
Casas et al.	2007	Severe acute pancreatitis	Single-center	22	11	11	[48]
Chen et al.	2011	Medical ICU	Single-center	98^b	49	49	[49]
Justo Meirelles et al.	2011	Traumatic brain injury	Single-center	22	12	10	[21]
Wang et al.	2013	Surgical ICU (severe acute pancreatitis)	Single-center	121^b	61	60	[22]
Sun et al.	2013	Surgical ICU (severe acute pancreatitis)	Single-center	60	30	30	[50]
Harvey et al.	2014	Mixed medical-surgical	Multi-center	2400	1200	1200	[16]

EN enteral nutrition ICU intensive care unit PN parenteral nutrition
^aTotal number includes number of ICU patients randomized in the trial, even if analysis was not according to intention-to-treat principle
^bPatients randomized to a third intervention group (combined enteral and parenteral nutrition) of the concerned trial were excluded from this meta-analysis

ISSN: 1364-8535