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Table 3 Comparison of enrollment criteria and resuscitation endpoints

From: Early goal-directed therapy in severe sepsis and septic shock: insights and comparisons to ProCESS, ProMISe, and ARISE

 

EGDT

ProCESS

ARISE

ProMISe

 

EGDT

Control

EGDT

PBST

UC

EGDT

Control

EGDT

Control

Temperature, °C

35.9

36.6

37.6

37.6

37.7

37.6

37.6

  

Heart rate, beats/min

117

114

113.7

114.6

114.5

104.9

104.7

  

Systolic blood pressure, mm Hg

106

109

100.2

102.1

99.9

78.8

79.6

77.7

78.4

Respiratory rate, breaths/min

31.8

30.2

25.4

25.1

25.3

24.5

25.1

  

Lactate, mM/L

7.7

6.9

4.8

5.0

4.8

4.4

4.2

 

5.1

Lactate >4, mM/L (%)

79

59

59.2

60.7

46

46.5

65.4

63.7

CVP, mmHg

5.3

6.1

   

>10

   

ScvO2, %

48.6

49.2

71

  

72.7

 

70.1

 

pH

7.31

7.32

7.33

7.31

7.34

    

PaCO2, mm Hg

31.5

30.6

35.7

38.9

36.9

35.2

35.5

  

MAP (6 h), mm Hg

95

81

77

79

76

76.5

75.3

76.5

76.5

CVP (6 h), mmHg

13.8

11.8

   

11.4

11.9

11.2

11.7

ScvO2 (6 h), %

77.3

66.0

   

75.9

 

74.2

 
  1. Open spaces indicate data not available
  2. ARISE Australasian Resuscitation in Sepsis Evaluation, CVP central venous pressure, EGDT Early Goal-Directed Therapy, MAP mean arterial pressure, PaCO 2 partial pressure of carbon dioxide, PBST protocol-based standard therapy, ProCESS Protocolized Care for Early Septic Shock, ProMISe Protocolized Management in Sepsis, ScvO 2 central venous oxygen saturation, UC usual care