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Table 3 Comparison of enrollment criteria and resuscitation endpoints

From: Early goal-directed therapy in severe sepsis and septic shock: insights and comparisons to ProCESS, ProMISe, and ARISE

  EGDT ProCESS ARISE ProMISe
  EGDT Control EGDT PBST UC EGDT Control EGDT Control
Temperature, °C 35.9 36.6 37.6 37.6 37.7 37.6 37.6   
Heart rate, beats/min 117 114 113.7 114.6 114.5 104.9 104.7   
Systolic blood pressure, mm Hg 106 109 100.2 102.1 99.9 78.8 79.6 77.7 78.4
Respiratory rate, breaths/min 31.8 30.2 25.4 25.1 25.3 24.5 25.1   
Lactate, mM/L 7.7 6.9 4.8 5.0 4.8 4.4 4.2   5.1
Lactate >4, mM/L (%) 79 59 59.2 60.7 46 46.5 65.4 63.7
CVP, mmHg 5.3 6.1     >10    
ScvO2, % 48.6 49.2 71    72.7   70.1  
pH 7.31 7.32 7.33 7.31 7.34     
PaCO2, mm Hg 31.5 30.6 35.7 38.9 36.9 35.2 35.5   
MAP (6 h), mm Hg 95 81 77 79 76 76.5 75.3 76.5 76.5
CVP (6 h), mmHg 13.8 11.8     11.4 11.9 11.2 11.7
ScvO2 (6 h), % 77.3 66.0     75.9   74.2  
  1. Open spaces indicate data not available
  2. ARISE Australasian Resuscitation in Sepsis Evaluation, CVP central venous pressure, EGDT Early Goal-Directed Therapy, MAP mean arterial pressure, PaCO 2 partial pressure of carbon dioxide, PBST protocol-based standard therapy, ProCESS Protocolized Care for Early Septic Shock, ProMISe Protocolized Management in Sepsis, ScvO 2 central venous oxygen saturation, UC usual care