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Table 1 Some potential advantages and disadvantages of using combination empiric therapy versus monotherapy

From: Advances in antibiotic therapy in the critically ill

Advantages

Disadvantages

Broader coverage that includes non-susceptible strains

Possible antagonism

Anti-bacterial synergy

Possible superinfection

Prevents emergence of resistance

May increase resistance

 

Increased toxicity

 

Increased costs

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Critical Care

ISSN: 1364-8535