| Univariate analysis | Multivariate analysis | ||||
---|---|---|---|---|---|---|
 | De-escalation (n = 110) | No de-escalation (n = 96) | Unadjusted odds ratio (95 % CI) | p valuea | Adjusted odds ratio (95 % CI) | p value |
At time of admission | ||||||
 Age, years | 61 (47–72) | 66 (51–75) | 0.98 (0.97–0.99) | 0.049 | – | – |
 Emergency surgery | 37 (34) | 44 (46) | 0.60 (0.34–1.05) | 0.087 |  |  |
 Anastomotic leakage | 45 (41) | 27 (28) | 1.76 (0.98–3.17) | 0.058 | – | – |
 Empiric antibiotic monotherapy | 13 (12) | 32 (33) | 0.26 (0.13–0.54) | <0.01 | – | – |
  Initial use of carbapenems | 35 (32) | 15 (16) | 2.52 (1.27–4.98) | 0.009 | 2.64 (1.01–6.91) | 0.047 |
  Initial use of vancomycin | 57 (52) | 23 (24) | 3.41 (1.87–6.21) | <0.0001 | 3.39 (1.46–7.87) | 0.004 |
  Initial use of aminoglycosides | 59 (54) | 33 (34) | 2.20 (1.25–3.88) | 0.007 | 2.31 (1.08–4.94) | 0.031 |
  Initial use of fluoroquinolones | 6 (5) | 11 (11) | 0.44 (0.15–1.22) | 0.134 |  |  |
  Initial use of antifungal agents | 47 (43) | 23 (24) | 2.36 (1.29–4.32) | 0.005 | – | – |
At day 3 | ||||||
 Presence of Enterococcus faecium | 8 (7) | 18 (19) | 0.33 (0.14–0.82) | 0.019 | – | – |
 Presence of streptococci | 31 (28) | 17 (18) | 1.82 (0.93–3.55) | 0.098 | – | – |
 Presence of staphylococci | 25 (23) | 35 (36) | 0.51 (0.27–0.94) | 0.032 | – | – |
 Presence of NFGNB | 8 (7) | 22 (23) | 0.26 (0.11–0.62) | 0.002 | 0.28 (0.09–0.89) | 0.031 |
 Presence of MDR strains | 23 (21) | 54 (56) | 0.20 (0.11– 0.37) | <0.0001 | 0.21 (0.09–0.52) | 0.0007 |
 Presence of fungi | 30 (27) | 41 (43) | 0.50 (0.28–0.90) | 0.027 | – | – |
 Adequate empiric therapy | 100 (91) | 37 (39) | 15.95 (7.38–34.40) | <0.0001 | 9.60 (4.02–22.97) | <0.0001 |